Neuroprotective mechanisms of 3-n-butylphthalide in neurodegenerative diseases
Since 3-n-butylphthalide (NBP) was approved by the China Food and Drug Administration for the treatment of acute ischemia stroke in 2002, a number of studies have investigated NBP worldwide. In recent years, NBP has also demonstrated potential as treatment of several neurodegenerative diseases, whic...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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D.A. Spandidos
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873419/ https://www.ncbi.nlm.nih.gov/pubmed/31798868 http://dx.doi.org/10.3892/br.2019.1246 |
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author | Luo, Rixin Wangqin, Runqi Zhu, Lihong Bi, Wei |
author_facet | Luo, Rixin Wangqin, Runqi Zhu, Lihong Bi, Wei |
author_sort | Luo, Rixin |
collection | PubMed |
description | Since 3-n-butylphthalide (NBP) was approved by the China Food and Drug Administration for the treatment of acute ischemia stroke in 2002, a number of studies have investigated NBP worldwide. In recent years, NBP has also demonstrated potential as treatment of several neurodegenerative diseases, which has increased the interest in its mechanisms of protection and action. Clinical studies and studies that used cell or animal models, have directly demonstrated neuroprotective effects of NBP via the following mechanisms: i) Inhibiting the inflammatory reaction; ii) reducing mitochondrial oxidative stress; iii) regulating apoptosis and autophagy; iv) inducing resistance to endoplasmic reticulum stress; and v) decreasing abnormal protein deposition. Therefore, NBP may be a potential drug for neurodegenerative diseases, and it is particularly important to identify the mechanism of NBP as it may assist with the development of new drugs for neurodegeneration. The present review summarizes the neuroprotective mechanisms of NBP and discusses new perspectives and prospects. The aim of the current review is to provide a new summary regarding NBP and its associated mechanisms. |
format | Online Article Text |
id | pubmed-6873419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-68734192019-12-03 Neuroprotective mechanisms of 3-n-butylphthalide in neurodegenerative diseases Luo, Rixin Wangqin, Runqi Zhu, Lihong Bi, Wei Biomed Rep Review Since 3-n-butylphthalide (NBP) was approved by the China Food and Drug Administration for the treatment of acute ischemia stroke in 2002, a number of studies have investigated NBP worldwide. In recent years, NBP has also demonstrated potential as treatment of several neurodegenerative diseases, which has increased the interest in its mechanisms of protection and action. Clinical studies and studies that used cell or animal models, have directly demonstrated neuroprotective effects of NBP via the following mechanisms: i) Inhibiting the inflammatory reaction; ii) reducing mitochondrial oxidative stress; iii) regulating apoptosis and autophagy; iv) inducing resistance to endoplasmic reticulum stress; and v) decreasing abnormal protein deposition. Therefore, NBP may be a potential drug for neurodegenerative diseases, and it is particularly important to identify the mechanism of NBP as it may assist with the development of new drugs for neurodegeneration. The present review summarizes the neuroprotective mechanisms of NBP and discusses new perspectives and prospects. The aim of the current review is to provide a new summary regarding NBP and its associated mechanisms. D.A. Spandidos 2019-12 2019-10-16 /pmc/articles/PMC6873419/ /pubmed/31798868 http://dx.doi.org/10.3892/br.2019.1246 Text en Copyright: © Luo et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Luo, Rixin Wangqin, Runqi Zhu, Lihong Bi, Wei Neuroprotective mechanisms of 3-n-butylphthalide in neurodegenerative diseases |
title | Neuroprotective mechanisms of 3-n-butylphthalide in neurodegenerative diseases |
title_full | Neuroprotective mechanisms of 3-n-butylphthalide in neurodegenerative diseases |
title_fullStr | Neuroprotective mechanisms of 3-n-butylphthalide in neurodegenerative diseases |
title_full_unstemmed | Neuroprotective mechanisms of 3-n-butylphthalide in neurodegenerative diseases |
title_short | Neuroprotective mechanisms of 3-n-butylphthalide in neurodegenerative diseases |
title_sort | neuroprotective mechanisms of 3-n-butylphthalide in neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873419/ https://www.ncbi.nlm.nih.gov/pubmed/31798868 http://dx.doi.org/10.3892/br.2019.1246 |
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