Cargando…

Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?

Degenerative disorders of joints, especially osteoarthritis (OA), result in persistent pain and disability and high costs to society. Nevertheless, the molecular mechanisms of OA have not yet been fully explained. OA is characterized by destruction of cartilage and loss of extracellular matrix (ECM)...

Descripción completa

Detalles Bibliográficos
Autores principales: Mianehsaz, Elaheh, Mirzaei, Hamid Reza, Mahjoubin-Tehran, Maryam, Rezaee, Alireza, Sahebnasagh, Roxana, Pourhanifeh, Mohammad Hossein, Mirzaei, Hamed, Hamblin, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873475/
https://www.ncbi.nlm.nih.gov/pubmed/31753036
http://dx.doi.org/10.1186/s13287-019-1445-0
_version_ 1783472665213796352
author Mianehsaz, Elaheh
Mirzaei, Hamid Reza
Mahjoubin-Tehran, Maryam
Rezaee, Alireza
Sahebnasagh, Roxana
Pourhanifeh, Mohammad Hossein
Mirzaei, Hamed
Hamblin, Michael R.
author_facet Mianehsaz, Elaheh
Mirzaei, Hamid Reza
Mahjoubin-Tehran, Maryam
Rezaee, Alireza
Sahebnasagh, Roxana
Pourhanifeh, Mohammad Hossein
Mirzaei, Hamed
Hamblin, Michael R.
author_sort Mianehsaz, Elaheh
collection PubMed
description Degenerative disorders of joints, especially osteoarthritis (OA), result in persistent pain and disability and high costs to society. Nevertheless, the molecular mechanisms of OA have not yet been fully explained. OA is characterized by destruction of cartilage and loss of extracellular matrix (ECM). It is generally agreed that there is an association between pro-inflammatory cytokines and the development of OA. There is increased expression of matrix metalloproteinase (MMP) and “a disintegrin and metalloproteinase with thrombospondin motifs” (ADAMTS). Mesenchymal stem cells (MSCs) have been explored as a new treatment for OA during the last decade. It has been suggested that paracrine secretion of trophic factors, in which exosomes have a crucial role, contributes to the mechanism of MSC-based treatment of OA. The paracrine secretion of exosomes may play a role in the repair of joint tissue as well as MSC-based treatments for other disorders. Exosomes isolated from various stem cells may contribute to tissue regeneration in the heart, limbs, skin, and other tissues. Recent studies have indicated that exosomes (or similar particles) derived from MSCs may suppress OA development. Herein, for first time, we summarize the recent findings of studies on various exosomes derived from MSCs and their effectiveness in the treatment of OA. Moreover, we highlight the likely mechanisms of actions of exosomes in OA.
format Online
Article
Text
id pubmed-6873475
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-68734752019-12-12 Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis? Mianehsaz, Elaheh Mirzaei, Hamid Reza Mahjoubin-Tehran, Maryam Rezaee, Alireza Sahebnasagh, Roxana Pourhanifeh, Mohammad Hossein Mirzaei, Hamed Hamblin, Michael R. Stem Cell Res Ther Review Degenerative disorders of joints, especially osteoarthritis (OA), result in persistent pain and disability and high costs to society. Nevertheless, the molecular mechanisms of OA have not yet been fully explained. OA is characterized by destruction of cartilage and loss of extracellular matrix (ECM). It is generally agreed that there is an association between pro-inflammatory cytokines and the development of OA. There is increased expression of matrix metalloproteinase (MMP) and “a disintegrin and metalloproteinase with thrombospondin motifs” (ADAMTS). Mesenchymal stem cells (MSCs) have been explored as a new treatment for OA during the last decade. It has been suggested that paracrine secretion of trophic factors, in which exosomes have a crucial role, contributes to the mechanism of MSC-based treatment of OA. The paracrine secretion of exosomes may play a role in the repair of joint tissue as well as MSC-based treatments for other disorders. Exosomes isolated from various stem cells may contribute to tissue regeneration in the heart, limbs, skin, and other tissues. Recent studies have indicated that exosomes (or similar particles) derived from MSCs may suppress OA development. Herein, for first time, we summarize the recent findings of studies on various exosomes derived from MSCs and their effectiveness in the treatment of OA. Moreover, we highlight the likely mechanisms of actions of exosomes in OA. BioMed Central 2019-11-21 /pmc/articles/PMC6873475/ /pubmed/31753036 http://dx.doi.org/10.1186/s13287-019-1445-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Mianehsaz, Elaheh
Mirzaei, Hamid Reza
Mahjoubin-Tehran, Maryam
Rezaee, Alireza
Sahebnasagh, Roxana
Pourhanifeh, Mohammad Hossein
Mirzaei, Hamed
Hamblin, Michael R.
Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?
title Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?
title_full Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?
title_fullStr Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?
title_full_unstemmed Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?
title_short Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?
title_sort mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873475/
https://www.ncbi.nlm.nih.gov/pubmed/31753036
http://dx.doi.org/10.1186/s13287-019-1445-0
work_keys_str_mv AT mianehsazelaheh mesenchymalstemcellderivedexosomesanewtherapeuticapproachtoosteoarthritis
AT mirzaeihamidreza mesenchymalstemcellderivedexosomesanewtherapeuticapproachtoosteoarthritis
AT mahjoubintehranmaryam mesenchymalstemcellderivedexosomesanewtherapeuticapproachtoosteoarthritis
AT rezaeealireza mesenchymalstemcellderivedexosomesanewtherapeuticapproachtoosteoarthritis
AT sahebnasaghroxana mesenchymalstemcellderivedexosomesanewtherapeuticapproachtoosteoarthritis
AT pourhanifehmohammadhossein mesenchymalstemcellderivedexosomesanewtherapeuticapproachtoosteoarthritis
AT mirzaeihamed mesenchymalstemcellderivedexosomesanewtherapeuticapproachtoosteoarthritis
AT hamblinmichaelr mesenchymalstemcellderivedexosomesanewtherapeuticapproachtoosteoarthritis