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Enhanced osteopontin splicing regulated by RUNX2 is HDAC-dependent and induces invasive phenotypes in NSCLC cells

BACKGROUND: Increased cell mobility is a signature when tumor cells undergo epithelial-to-mesenchymal transition. TGF-β is a key stimulating factor to promote the transcription of a variety of downstream genes to accelerate cancer progression and metastasis, including osteopontin (OPN) which exists...

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Detalles Bibliográficos
Autores principales:	Huang, Jing, Chang, Siyuan, Lu, Yabin, Wang, Jing, Si, Yang, Zhang, Lijian, Cheng, Shan, Jiang, Wen G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873507/ https://www.ncbi.nlm.nih.gov/pubmed/31832019 http://dx.doi.org/10.1186/s12935-019-1033-5

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