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Susceptibility of BAFF-var allele carriers to severe SLE with occurrence of lupus nephritis
BACKGROUND: Dysregulation of the B-cell activating factor (BAFF) system is involved in the pathogenesis of systemic lupus erythematosus (SLE). Increased serum concentrations of BAFF are related to lupus nephritis and disease activity among SLE patients. Recently, a variant of the BAFF-encoding gene,...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873527/ https://www.ncbi.nlm.nih.gov/pubmed/31752784 http://dx.doi.org/10.1186/s12882-019-1623-4 |
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author | Friebus-Kardash, Justa Trendelenburg, Marten Eisenberger, Ute Ribi, Camillo Chizzolini, Carlo Huynh-Do, Uyen Lang, Karl Sebastian Wilde, Benjamin Kribben, Andreas Witzke, Oliver Dolff, Sebastian Hardt, Cornelia |
author_facet | Friebus-Kardash, Justa Trendelenburg, Marten Eisenberger, Ute Ribi, Camillo Chizzolini, Carlo Huynh-Do, Uyen Lang, Karl Sebastian Wilde, Benjamin Kribben, Andreas Witzke, Oliver Dolff, Sebastian Hardt, Cornelia |
author_sort | Friebus-Kardash, Justa |
collection | PubMed |
description | BACKGROUND: Dysregulation of the B-cell activating factor (BAFF) system is involved in the pathogenesis of systemic lupus erythematosus (SLE). Increased serum concentrations of BAFF are related to lupus nephritis and disease activity among SLE patients. Recently, a variant of the BAFF-encoding gene, BAFF-var, was identified to be associated with autoimmune diseases, in particular SLE, and to promote the production of soluble BAFF. The present study aimed to assess the prevalence of BAFF-var in a cohort of 195 SLE patients and to analyze the association of the BAFF-var genotype (TNSF13B) with various manifestations of SLE. METHODS: A cohort of 195 SLE patients from Central Europe, including 153 patients from the Swiss SLE Cohort Study and 42 patients from the University Hospital Essen, Germany, underwent genotyping for detection of BAFF-var allele. RESULTS: Of the 195 patients, 18 (9.2%) tested positive for BAFF-var variant according to the minor allele frequency of 4.6%. The presence of BAFF-var was associated with the occurrence of lupus nephritis (p = 0.038) (p = 0.03 and p = 0.003). Among various organ manifestations of SLE, the presence of BAFF-var was associated with the occurrence of lupus nephritis (p = 0.038; odds ratio [OR], 2.4; 95% confidence interval [CI], 0.89–6.34) and renal activity markers such as proteinuria and hematuria (p = 0.03; OR, 2.4; 95% CI, 0.9–6.4 for proteinuria; p = 0.003; OR, 3.9; 95% CI, 1.43–10.76 for hematuria). SLE patients carrying the BAFF-var allele exhibited increased disease activity at study entry, as determined by the physician’s global assessment (PGA: p = 0.002; OR, 4.8; 95% CI, 1.54–14.93) and the SLE Disease Activity Index (p = 0.012; OR, 3.5; 95% CI, 1.12–11.18). Consistent with that, the percentage of patients treated with immunosuppressive agents at study entry was higher among those carrying the BAFF-var allele than among those tested negative for BAFF-var (p = 0.006; OR, 3.7; 95% CI, 1.27–10.84). CONCLUSIONS: Our results indicate an association between the BAFF-var genotype and increased severity of SLE. Determining the BAFF-var status of SLE patients may improve the risk stratification of patients for whom the development of lupus nephritis is more likely and thus may be helpful in the follow-up care and treatment of SLE patients. |
format | Online Article Text |
id | pubmed-6873527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68735272019-12-12 Susceptibility of BAFF-var allele carriers to severe SLE with occurrence of lupus nephritis Friebus-Kardash, Justa Trendelenburg, Marten Eisenberger, Ute Ribi, Camillo Chizzolini, Carlo Huynh-Do, Uyen Lang, Karl Sebastian Wilde, Benjamin Kribben, Andreas Witzke, Oliver Dolff, Sebastian Hardt, Cornelia BMC Nephrol Research Article BACKGROUND: Dysregulation of the B-cell activating factor (BAFF) system is involved in the pathogenesis of systemic lupus erythematosus (SLE). Increased serum concentrations of BAFF are related to lupus nephritis and disease activity among SLE patients. Recently, a variant of the BAFF-encoding gene, BAFF-var, was identified to be associated with autoimmune diseases, in particular SLE, and to promote the production of soluble BAFF. The present study aimed to assess the prevalence of BAFF-var in a cohort of 195 SLE patients and to analyze the association of the BAFF-var genotype (TNSF13B) with various manifestations of SLE. METHODS: A cohort of 195 SLE patients from Central Europe, including 153 patients from the Swiss SLE Cohort Study and 42 patients from the University Hospital Essen, Germany, underwent genotyping for detection of BAFF-var allele. RESULTS: Of the 195 patients, 18 (9.2%) tested positive for BAFF-var variant according to the minor allele frequency of 4.6%. The presence of BAFF-var was associated with the occurrence of lupus nephritis (p = 0.038) (p = 0.03 and p = 0.003). Among various organ manifestations of SLE, the presence of BAFF-var was associated with the occurrence of lupus nephritis (p = 0.038; odds ratio [OR], 2.4; 95% confidence interval [CI], 0.89–6.34) and renal activity markers such as proteinuria and hematuria (p = 0.03; OR, 2.4; 95% CI, 0.9–6.4 for proteinuria; p = 0.003; OR, 3.9; 95% CI, 1.43–10.76 for hematuria). SLE patients carrying the BAFF-var allele exhibited increased disease activity at study entry, as determined by the physician’s global assessment (PGA: p = 0.002; OR, 4.8; 95% CI, 1.54–14.93) and the SLE Disease Activity Index (p = 0.012; OR, 3.5; 95% CI, 1.12–11.18). Consistent with that, the percentage of patients treated with immunosuppressive agents at study entry was higher among those carrying the BAFF-var allele than among those tested negative for BAFF-var (p = 0.006; OR, 3.7; 95% CI, 1.27–10.84). CONCLUSIONS: Our results indicate an association between the BAFF-var genotype and increased severity of SLE. Determining the BAFF-var status of SLE patients may improve the risk stratification of patients for whom the development of lupus nephritis is more likely and thus may be helpful in the follow-up care and treatment of SLE patients. BioMed Central 2019-11-21 /pmc/articles/PMC6873527/ /pubmed/31752784 http://dx.doi.org/10.1186/s12882-019-1623-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Friebus-Kardash, Justa Trendelenburg, Marten Eisenberger, Ute Ribi, Camillo Chizzolini, Carlo Huynh-Do, Uyen Lang, Karl Sebastian Wilde, Benjamin Kribben, Andreas Witzke, Oliver Dolff, Sebastian Hardt, Cornelia Susceptibility of BAFF-var allele carriers to severe SLE with occurrence of lupus nephritis |
title | Susceptibility of BAFF-var allele carriers to severe SLE with occurrence of lupus nephritis |
title_full | Susceptibility of BAFF-var allele carriers to severe SLE with occurrence of lupus nephritis |
title_fullStr | Susceptibility of BAFF-var allele carriers to severe SLE with occurrence of lupus nephritis |
title_full_unstemmed | Susceptibility of BAFF-var allele carriers to severe SLE with occurrence of lupus nephritis |
title_short | Susceptibility of BAFF-var allele carriers to severe SLE with occurrence of lupus nephritis |
title_sort | susceptibility of baff-var allele carriers to severe sle with occurrence of lupus nephritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873527/ https://www.ncbi.nlm.nih.gov/pubmed/31752784 http://dx.doi.org/10.1186/s12882-019-1623-4 |
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