Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1

BACKGROUND: Circulating tumour cells (CTCs), especially mesenchymal CTCs, are important determinants of metastasis, which leads to most recurrence and mortality in hepatocellular carcinoma (HCC). However, little is known about the underlying mechanisms of CTC colonisation in pre-metastatic niches. M...

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Detalles Bibliográficos
Autores principales: Tang, Yujun, Lu, Yishi, Chen, Yuan, Luo, Lei, Cai, Lei, Peng, Bangjian, Huang, Wenbin, Liao, Hangyu, Zhao, Liang, Pan, Mingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873584/
https://www.ncbi.nlm.nih.gov/pubmed/31752959
http://dx.doi.org/10.1186/s13046-019-1475-6

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