NLRC4 Mutation in flagellin-derived peptide CBLB502 ligand-binding domain reduces the inflammatory response but not radioprotective activity

Bacterial flagellin is a pathogen-associated molecular pattern recognized by surface-localized Toll-like receptor 5 (TLR5) and cytosolic NOD-like receptor protein 4 (NLRC4). CBLB502, derived from Salmonella flagellin, exhibits high radioprotective efficacy in mice and primates by regulating TLR5 and...

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Detalles Bibliográficos
Autores principales: Lai, Lili, Yang, Ganggang, Yao, Xuelian, Wang, Lei, Zhan, Yiqun, Yu, Miao, Yin, Ronghua, Li, Changyan, Yang, Xiaoming, Ge, Changhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873615/
https://www.ncbi.nlm.nih.gov/pubmed/31599956
http://dx.doi.org/10.1093/jrr/rrz062

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