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lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration

With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and intervertebral disc degeneration (IDD), heavier financial and social burdens need to be faced. Unfortunately, there is no satisfactory clinical method to target the pathophysiology of cartilage-related diseas...

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Autores principales: Zhu, Jian, Yu, Wei, Wang, Yitian, Xia, Kaishun, Huang, Yuluan, Xu, Ankai, Chen, Qixin, Liu, Bing, Tao, Huimin, Li, Fangcai, Liang, Chengzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873685/
https://www.ncbi.nlm.nih.gov/pubmed/31753016
http://dx.doi.org/10.1186/s13287-019-1458-8
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author Zhu, Jian
Yu, Wei
Wang, Yitian
Xia, Kaishun
Huang, Yuluan
Xu, Ankai
Chen, Qixin
Liu, Bing
Tao, Huimin
Li, Fangcai
Liang, Chengzhen
author_facet Zhu, Jian
Yu, Wei
Wang, Yitian
Xia, Kaishun
Huang, Yuluan
Xu, Ankai
Chen, Qixin
Liu, Bing
Tao, Huimin
Li, Fangcai
Liang, Chengzhen
author_sort Zhu, Jian
collection PubMed
description With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and intervertebral disc degeneration (IDD), heavier financial and social burdens need to be faced. Unfortunately, there is no satisfactory clinical method to target the pathophysiology of cartilage-related diseases. Many gene expressions, signaling pathways, and biomechanical dysregulations were involved in cartilage development, degeneration, and regeneration. However, the underlying mechanism was not clearly understood. Recently, lots of long non-coding RNAs (lncRNAs) were identified in the biological processes, including cartilage development, degeneration, and regeneration. It is clear that lncRNAs were important in regulating gene expression and maintaining chondrocyte phenotypes and homeostasis. In this review, we summarize the recent researches studying lncRNAs’ expression and function in cartilage development, degeneration, and regeneration and illustrate the potential mechanism of how they act in the pathologic process. With continued efforts, regulating lncRNA expression in the cartilage regeneration may be a promising biological treatment approach.
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spelling pubmed-68736852019-11-25 lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration Zhu, Jian Yu, Wei Wang, Yitian Xia, Kaishun Huang, Yuluan Xu, Ankai Chen, Qixin Liu, Bing Tao, Huimin Li, Fangcai Liang, Chengzhen Stem Cell Res Ther Review With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and intervertebral disc degeneration (IDD), heavier financial and social burdens need to be faced. Unfortunately, there is no satisfactory clinical method to target the pathophysiology of cartilage-related diseases. Many gene expressions, signaling pathways, and biomechanical dysregulations were involved in cartilage development, degeneration, and regeneration. However, the underlying mechanism was not clearly understood. Recently, lots of long non-coding RNAs (lncRNAs) were identified in the biological processes, including cartilage development, degeneration, and regeneration. It is clear that lncRNAs were important in regulating gene expression and maintaining chondrocyte phenotypes and homeostasis. In this review, we summarize the recent researches studying lncRNAs’ expression and function in cartilage development, degeneration, and regeneration and illustrate the potential mechanism of how they act in the pathologic process. With continued efforts, regulating lncRNA expression in the cartilage regeneration may be a promising biological treatment approach. BioMed Central 2019-11-21 /pmc/articles/PMC6873685/ /pubmed/31753016 http://dx.doi.org/10.1186/s13287-019-1458-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhu, Jian
Yu, Wei
Wang, Yitian
Xia, Kaishun
Huang, Yuluan
Xu, Ankai
Chen, Qixin
Liu, Bing
Tao, Huimin
Li, Fangcai
Liang, Chengzhen
lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration
title lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration
title_full lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration
title_fullStr lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration
title_full_unstemmed lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration
title_short lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration
title_sort lncrnas: function and mechanism in cartilage development, degeneration, and regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873685/
https://www.ncbi.nlm.nih.gov/pubmed/31753016
http://dx.doi.org/10.1186/s13287-019-1458-8
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