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Oncologic outcomes comparison of partial ureterectomy and radical nephroureterectomy for urothelial carcinoma

BACKGROUND: The appropriate application of various treatment for upper tract urothelial carcinomas (UTUCs) is the key to prolong the survival of UTUC patients. Herein, we used data in our database to assess the oncological outcomes between partial ureterectomy (PU) and radical nephroureterectomy (RN...

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Autores principales: Li, Shengxian, Pan, Yuchen, Hu, Jinghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873718/
https://www.ncbi.nlm.nih.gov/pubmed/31752789
http://dx.doi.org/10.1186/s12894-019-0557-2
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author Li, Shengxian
Pan, Yuchen
Hu, Jinghai
author_facet Li, Shengxian
Pan, Yuchen
Hu, Jinghai
author_sort Li, Shengxian
collection PubMed
description BACKGROUND: The appropriate application of various treatment for upper tract urothelial carcinomas (UTUCs) is the key to prolong the survival of UTUC patients. Herein, we used data in our database to assess the oncological outcomes between partial ureterectomy (PU) and radical nephroureterectomy (RNU). METHODS: From 2007 to 2014, 255 patients with UTUC undergoing PU or RNU in our hospital database were investigated. Perioperative, postoperative data, and pathologic outcomes were obtained from our database. Cancer-specific survival (CSS) was assessed through the Kaplan-Meier method with Cox regression models to test the effect of these two surgery types. RESULTS: The mean length of follow-up was 35.8 months (interquartile range 10–47 months). Patients with high pT stage (pT2–4) suffered shorter survival span (HR: 9.370, 95% CI: 2.956–29.697, P < 0.001). There were no significant differences in CSS between PU and RNU (P = 0.964). In the sub-analysis, CSS for RNU and PU showed no significant difference for pTa–1 or pT2–4 tumor patients (P = 0.516, P = 0.475, respectively). CONCLUSIONS: PU is not inferior to RNU in oncologic outcomes. Furthermore, PU is generally recognized with less invasive and better renal function preservation compared with RNU. Thus, PU would be rational for specific patients with UTUCs.
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spelling pubmed-68737182019-11-25 Oncologic outcomes comparison of partial ureterectomy and radical nephroureterectomy for urothelial carcinoma Li, Shengxian Pan, Yuchen Hu, Jinghai BMC Urol Research Article BACKGROUND: The appropriate application of various treatment for upper tract urothelial carcinomas (UTUCs) is the key to prolong the survival of UTUC patients. Herein, we used data in our database to assess the oncological outcomes between partial ureterectomy (PU) and radical nephroureterectomy (RNU). METHODS: From 2007 to 2014, 255 patients with UTUC undergoing PU or RNU in our hospital database were investigated. Perioperative, postoperative data, and pathologic outcomes were obtained from our database. Cancer-specific survival (CSS) was assessed through the Kaplan-Meier method with Cox regression models to test the effect of these two surgery types. RESULTS: The mean length of follow-up was 35.8 months (interquartile range 10–47 months). Patients with high pT stage (pT2–4) suffered shorter survival span (HR: 9.370, 95% CI: 2.956–29.697, P < 0.001). There were no significant differences in CSS between PU and RNU (P = 0.964). In the sub-analysis, CSS for RNU and PU showed no significant difference for pTa–1 or pT2–4 tumor patients (P = 0.516, P = 0.475, respectively). CONCLUSIONS: PU is not inferior to RNU in oncologic outcomes. Furthermore, PU is generally recognized with less invasive and better renal function preservation compared with RNU. Thus, PU would be rational for specific patients with UTUCs. BioMed Central 2019-11-21 /pmc/articles/PMC6873718/ /pubmed/31752789 http://dx.doi.org/10.1186/s12894-019-0557-2 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Li, Shengxian
Pan, Yuchen
Hu, Jinghai
Oncologic outcomes comparison of partial ureterectomy and radical nephroureterectomy for urothelial carcinoma
title Oncologic outcomes comparison of partial ureterectomy and radical nephroureterectomy for urothelial carcinoma
title_full Oncologic outcomes comparison of partial ureterectomy and radical nephroureterectomy for urothelial carcinoma
title_fullStr Oncologic outcomes comparison of partial ureterectomy and radical nephroureterectomy for urothelial carcinoma
title_full_unstemmed Oncologic outcomes comparison of partial ureterectomy and radical nephroureterectomy for urothelial carcinoma
title_short Oncologic outcomes comparison of partial ureterectomy and radical nephroureterectomy for urothelial carcinoma
title_sort oncologic outcomes comparison of partial ureterectomy and radical nephroureterectomy for urothelial carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873718/
https://www.ncbi.nlm.nih.gov/pubmed/31752789
http://dx.doi.org/10.1186/s12894-019-0557-2
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