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Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis
BACKGROUND: We have performed this study to evaluate the association between H19 rs217727 polymorphism and the risk of cancer. METHODS: An odds ratio (OR) with a 95% confidence interval (CI) was applied to determine a potential association. RESULTS: A total of 17 case–control publications were selec...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873771/ https://www.ncbi.nlm.nih.gov/pubmed/31752724 http://dx.doi.org/10.1186/s12881-019-0904-x |
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author | Wang, Xue Zhong, Jialing Chen, Fang Hu, Kang Sun, Suhong Leng, Yuanxiu Chen, Xumei Gan, Fengjiao Pan, Yana Luo, Qing |
author_facet | Wang, Xue Zhong, Jialing Chen, Fang Hu, Kang Sun, Suhong Leng, Yuanxiu Chen, Xumei Gan, Fengjiao Pan, Yana Luo, Qing |
author_sort | Wang, Xue |
collection | PubMed |
description | BACKGROUND: We have performed this study to evaluate the association between H19 rs217727 polymorphism and the risk of cancer. METHODS: An odds ratio (OR) with a 95% confidence interval (CI) was applied to determine a potential association. RESULTS: A total of 17 case–control publications were selected. This meta-analysis showed that H19 rs217727 has a significant increased association with cancer risk in allelic, homozygous, heterozygote, dominant and recessive models (T vs C: OR = 1.16, 95% CI = 1.06–1.27, I(2) = 75.7; TT vs CC: OR = 1.29, 95% CI = 1.06–1.56, I(2) = 71.6; CT vs CC: OR = 1.15, 95% CI = 1.01–1.31, I(2) = 75.4; CT + TT vs CC: OR = 1.20, 95% CI = 1.05–1.36, I(2) = 76.5; TT vs CT + CC: OR = 1.22, 95% CI = 1.02–1.45, I(2) = 70.6;). In the subgroup analysis of smoking status, both smokers and nonsmokers showed an increase in cancer risk in allelic, homozygous, dominant and heterozygote models. CONCLUSION: This meta-analysis revealed H19 rs217727 may influence cancer susceptibility. |
format | Online Article Text |
id | pubmed-6873771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68737712019-11-25 Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis Wang, Xue Zhong, Jialing Chen, Fang Hu, Kang Sun, Suhong Leng, Yuanxiu Chen, Xumei Gan, Fengjiao Pan, Yana Luo, Qing BMC Med Genet Research Article BACKGROUND: We have performed this study to evaluate the association between H19 rs217727 polymorphism and the risk of cancer. METHODS: An odds ratio (OR) with a 95% confidence interval (CI) was applied to determine a potential association. RESULTS: A total of 17 case–control publications were selected. This meta-analysis showed that H19 rs217727 has a significant increased association with cancer risk in allelic, homozygous, heterozygote, dominant and recessive models (T vs C: OR = 1.16, 95% CI = 1.06–1.27, I(2) = 75.7; TT vs CC: OR = 1.29, 95% CI = 1.06–1.56, I(2) = 71.6; CT vs CC: OR = 1.15, 95% CI = 1.01–1.31, I(2) = 75.4; CT + TT vs CC: OR = 1.20, 95% CI = 1.05–1.36, I(2) = 76.5; TT vs CT + CC: OR = 1.22, 95% CI = 1.02–1.45, I(2) = 70.6;). In the subgroup analysis of smoking status, both smokers and nonsmokers showed an increase in cancer risk in allelic, homozygous, dominant and heterozygote models. CONCLUSION: This meta-analysis revealed H19 rs217727 may influence cancer susceptibility. BioMed Central 2019-11-21 /pmc/articles/PMC6873771/ /pubmed/31752724 http://dx.doi.org/10.1186/s12881-019-0904-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Wang, Xue Zhong, Jialing Chen, Fang Hu, Kang Sun, Suhong Leng, Yuanxiu Chen, Xumei Gan, Fengjiao Pan, Yana Luo, Qing Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis |
title | Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis |
title_full | Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis |
title_fullStr | Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis |
title_full_unstemmed | Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis |
title_short | Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis |
title_sort | association between lncrna h19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873771/ https://www.ncbi.nlm.nih.gov/pubmed/31752724 http://dx.doi.org/10.1186/s12881-019-0904-x |
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