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Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis

BACKGROUND: We have performed this study to evaluate the association between H19 rs217727 polymorphism and the risk of cancer. METHODS: An odds ratio (OR) with a 95% confidence interval (CI) was applied to determine a potential association. RESULTS: A total of 17 case–control publications were selec...

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Autores principales: Wang, Xue, Zhong, Jialing, Chen, Fang, Hu, Kang, Sun, Suhong, Leng, Yuanxiu, Chen, Xumei, Gan, Fengjiao, Pan, Yana, Luo, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873771/
https://www.ncbi.nlm.nih.gov/pubmed/31752724
http://dx.doi.org/10.1186/s12881-019-0904-x
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author Wang, Xue
Zhong, Jialing
Chen, Fang
Hu, Kang
Sun, Suhong
Leng, Yuanxiu
Chen, Xumei
Gan, Fengjiao
Pan, Yana
Luo, Qing
author_facet Wang, Xue
Zhong, Jialing
Chen, Fang
Hu, Kang
Sun, Suhong
Leng, Yuanxiu
Chen, Xumei
Gan, Fengjiao
Pan, Yana
Luo, Qing
author_sort Wang, Xue
collection PubMed
description BACKGROUND: We have performed this study to evaluate the association between H19 rs217727 polymorphism and the risk of cancer. METHODS: An odds ratio (OR) with a 95% confidence interval (CI) was applied to determine a potential association. RESULTS: A total of 17 case–control publications were selected. This meta-analysis showed that H19 rs217727 has a significant increased association with cancer risk in allelic, homozygous, heterozygote, dominant and recessive models (T vs C: OR = 1.16, 95% CI = 1.06–1.27, I(2) = 75.7; TT vs CC: OR = 1.29, 95% CI = 1.06–1.56, I(2) = 71.6; CT vs CC: OR = 1.15, 95% CI = 1.01–1.31, I(2) = 75.4; CT + TT vs CC: OR = 1.20, 95% CI = 1.05–1.36, I(2) = 76.5; TT vs CT + CC: OR = 1.22, 95% CI = 1.02–1.45, I(2) = 70.6;). In the subgroup analysis of smoking status, both smokers and nonsmokers showed an increase in cancer risk in allelic, homozygous, dominant and heterozygote models. CONCLUSION: This meta-analysis revealed H19 rs217727 may influence cancer susceptibility.
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spelling pubmed-68737712019-11-25 Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis Wang, Xue Zhong, Jialing Chen, Fang Hu, Kang Sun, Suhong Leng, Yuanxiu Chen, Xumei Gan, Fengjiao Pan, Yana Luo, Qing BMC Med Genet Research Article BACKGROUND: We have performed this study to evaluate the association between H19 rs217727 polymorphism and the risk of cancer. METHODS: An odds ratio (OR) with a 95% confidence interval (CI) was applied to determine a potential association. RESULTS: A total of 17 case–control publications were selected. This meta-analysis showed that H19 rs217727 has a significant increased association with cancer risk in allelic, homozygous, heterozygote, dominant and recessive models (T vs C: OR = 1.16, 95% CI = 1.06–1.27, I(2) = 75.7; TT vs CC: OR = 1.29, 95% CI = 1.06–1.56, I(2) = 71.6; CT vs CC: OR = 1.15, 95% CI = 1.01–1.31, I(2) = 75.4; CT + TT vs CC: OR = 1.20, 95% CI = 1.05–1.36, I(2) = 76.5; TT vs CT + CC: OR = 1.22, 95% CI = 1.02–1.45, I(2) = 70.6;). In the subgroup analysis of smoking status, both smokers and nonsmokers showed an increase in cancer risk in allelic, homozygous, dominant and heterozygote models. CONCLUSION: This meta-analysis revealed H19 rs217727 may influence cancer susceptibility. BioMed Central 2019-11-21 /pmc/articles/PMC6873771/ /pubmed/31752724 http://dx.doi.org/10.1186/s12881-019-0904-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wang, Xue
Zhong, Jialing
Chen, Fang
Hu, Kang
Sun, Suhong
Leng, Yuanxiu
Chen, Xumei
Gan, Fengjiao
Pan, Yana
Luo, Qing
Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis
title Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis
title_full Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis
title_fullStr Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis
title_full_unstemmed Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis
title_short Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis
title_sort association between lncrna h19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873771/
https://www.ncbi.nlm.nih.gov/pubmed/31752724
http://dx.doi.org/10.1186/s12881-019-0904-x
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