Oriented attachment of V(NAR) proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance

Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (V(NAR)) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid–polyethylene glycol (...

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Autores principales: Nogueira, João C. F., Greene, Michelle K., Richards, Daniel A., Furby, Alexander O., Steven, John, Porter, Andrew, Barelle, Caroline, Scott, Christopher J., Chudasama, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873773/
https://www.ncbi.nlm.nih.gov/pubmed/31204425
http://dx.doi.org/10.1039/c9cc02655j
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author Nogueira, João C. F.
Greene, Michelle K.
Richards, Daniel A.
Furby, Alexander O.
Steven, John
Porter, Andrew
Barelle, Caroline
Scott, Christopher J.
Chudasama, Vijay
author_facet Nogueira, João C. F.
Greene, Michelle K.
Richards, Daniel A.
Furby, Alexander O.
Steven, John
Porter, Andrew
Barelle, Caroline
Scott, Christopher J.
Chudasama, Vijay
author_sort Nogueira, João C. F.
collection PubMed
description Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (V(NAR)) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid–polyethylene glycol (PLGA–PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated.
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spelling pubmed-68737732019-12-09 Oriented attachment of V(NAR) proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance Nogueira, João C. F. Greene, Michelle K. Richards, Daniel A. Furby, Alexander O. Steven, John Porter, Andrew Barelle, Caroline Scott, Christopher J. Chudasama, Vijay Chem Commun (Camb) Chemistry Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (V(NAR)) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid–polyethylene glycol (PLGA–PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated. Royal Society of Chemistry 2019-07-07 2019-05-29 /pmc/articles/PMC6873773/ /pubmed/31204425 http://dx.doi.org/10.1039/c9cc02655j Text en This journal is © The Royal Society of Chemistry 2019 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Nogueira, João C. F.
Greene, Michelle K.
Richards, Daniel A.
Furby, Alexander O.
Steven, John
Porter, Andrew
Barelle, Caroline
Scott, Christopher J.
Chudasama, Vijay
Oriented attachment of V(NAR) proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance
title Oriented attachment of V(NAR) proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance
title_full Oriented attachment of V(NAR) proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance
title_fullStr Oriented attachment of V(NAR) proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance
title_full_unstemmed Oriented attachment of V(NAR) proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance
title_short Oriented attachment of V(NAR) proteins, via site-selective modification, on PLGA–PEG nanoparticles enhances nanoconjugate performance
title_sort oriented attachment of v(nar) proteins, via site-selective modification, on plga–peg nanoparticles enhances nanoconjugate performance
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873773/
https://www.ncbi.nlm.nih.gov/pubmed/31204425
http://dx.doi.org/10.1039/c9cc02655j
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