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DYRK1A Overexpression Alters Cognition and Neural-Related Proteomic Pathways in the Hippocampus That Are Rescued by Green Tea Extract and/or Environmental Enrichment

Down syndrome (DS), caused by trisomy of chromosome 21, is the most common genetic cause of intellectual disability. We recently discovered that green tea extracts containing epigallocatechin-3-gallate (EGCG) improve cognition in mice transgenic for Dyrk1a (TgDyrk1A) and in a trisomic DS mouse model...

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Detalles Bibliográficos
Autores principales:	De Toma, Ilario, Ortega, Mireia, Aloy, Patrick, Sabidó, Eduard, Dierssen, Mara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873902/ https://www.ncbi.nlm.nih.gov/pubmed/31803016 http://dx.doi.org/10.3389/fnmol.2019.00272

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