Cargando…
DYRK1A Overexpression Alters Cognition and Neural-Related Proteomic Pathways in the Hippocampus That Are Rescued by Green Tea Extract and/or Environmental Enrichment
Down syndrome (DS), caused by trisomy of chromosome 21, is the most common genetic cause of intellectual disability. We recently discovered that green tea extracts containing epigallocatechin-3-gallate (EGCG) improve cognition in mice transgenic for Dyrk1a (TgDyrk1A) and in a trisomic DS mouse model...
Autores principales: | De Toma, Ilario, Ortega, Mireia, Aloy, Patrick, Sabidó, Eduard, Dierssen, Mara |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873902/ https://www.ncbi.nlm.nih.gov/pubmed/31803016 http://dx.doi.org/10.3389/fnmol.2019.00272 |
Ejemplares similares
-
Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene
por: Ortega, Mireia, et al.
Publicado: (2022) -
Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup(®) Dietary Supplement: Role of Green Tea Catechins
por: Gu, Yuchen, et al.
Publicado: (2020) -
Re-establishment of the epigenetic state and rescue of kinome deregulation in Ts65Dn mice upon treatment with green tea extract and environmental enrichment
por: De Toma, I., et al.
Publicado: (2020) -
Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A
por: Guedj, Fayçal, et al.
Publicado: (2009) -
Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19
por: De Toma, Ilario, et al.
Publicado: (2021)