Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva‐Derived Endothelial Cells

Fibrodysplasia ossificans progressiva (FOP) is an extremely rare congenital form of heterotopic ossification (HO), caused by heterozygous mutations in the activin A type I receptor (ACVR1), that encodes the bone morphogenetic protein (BMP) type I receptor ALK2. These mutations enable ALK2 to induce...

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Detalles Bibliográficos
Autores principales: Sánchez‐Duffhues, Gonzalo, Williams, Eleanor, Benderitter, Pascal, Orlova, Valeria, van Wijhe, Michiel, Garcia de Vinuesa, Amaya, Kerr, Georgina, Caradec, Josselin, Lodder, Kirsten, de Boer, Hetty C., Goumans, Marie‐José, Eekhoff, Elisabeth M W, Morales‐Piga, Antonio, Bachiller‐Corral, Javier, Koolwijk, Pieter, Bullock, Alex N., Hoflack, Jan, ten Dijke, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874179/
https://www.ncbi.nlm.nih.gov/pubmed/31768489
http://dx.doi.org/10.1002/jbm4.10230

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