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Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017

Streptococcus suis is an emerging agent of zoonotic bacterial meningitis in Asia. We describe the epidemiology of S. suis cases and clinical signs and microbiological findings in persons with meningitis in Bali, Indonesia, using patient data and bacterial cultures of cerebrospinal fluid collected du...

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Autores principales: Susilawathi, Ni Made, Tarini, Ni Made Adi, Fatmawati, Ni Nengah Dwi, Mayura, Putu I.B., Suryapraba, Anak Agung Ayu, Subrata, Made, Sudewi, Anak Agung Raka, Mahardika, Gusti Ngurah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874276/
https://www.ncbi.nlm.nih.gov/pubmed/31742523
http://dx.doi.org/10.3201/eid2512.181709
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author Susilawathi, Ni Made
Tarini, Ni Made Adi
Fatmawati, Ni Nengah Dwi
Mayura, Putu I.B.
Suryapraba, Anak Agung Ayu
Subrata, Made
Sudewi, Anak Agung Raka
Mahardika, Gusti Ngurah
author_facet Susilawathi, Ni Made
Tarini, Ni Made Adi
Fatmawati, Ni Nengah Dwi
Mayura, Putu I.B.
Suryapraba, Anak Agung Ayu
Subrata, Made
Sudewi, Anak Agung Raka
Mahardika, Gusti Ngurah
author_sort Susilawathi, Ni Made
collection PubMed
description Streptococcus suis is an emerging agent of zoonotic bacterial meningitis in Asia. We describe the epidemiology of S. suis cases and clinical signs and microbiological findings in persons with meningitis in Bali, Indonesia, using patient data and bacterial cultures of cerebrospinal fluid collected during 2014–2017. We conducted microbiological assays using the fully automatic VITEK 2 COMPACT system. We amplified and sequenced gene fragments of glutamate dehydrogenase and recombination/repair protein and conducted PCR serotyping to confirm some serotypes. Of 71 cases, 44 were confirmed as S. suis; 29 isolates were serotype 2. The average patient age was 48.1 years, and 89% of patients were male. Seventy-seven percent of patients with confirmed cases recovered without complications; 11% recovered with septic shock, 7% with deafness, and 2% with deafness and arthritis. The case-fatality rate was 11%. Awareness of S. suis infection risk must be increased in health promotion activities in Bali.
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spelling pubmed-68742762019-12-01 Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017 Susilawathi, Ni Made Tarini, Ni Made Adi Fatmawati, Ni Nengah Dwi Mayura, Putu I.B. Suryapraba, Anak Agung Ayu Subrata, Made Sudewi, Anak Agung Raka Mahardika, Gusti Ngurah Emerg Infect Dis Research Streptococcus suis is an emerging agent of zoonotic bacterial meningitis in Asia. We describe the epidemiology of S. suis cases and clinical signs and microbiological findings in persons with meningitis in Bali, Indonesia, using patient data and bacterial cultures of cerebrospinal fluid collected during 2014–2017. We conducted microbiological assays using the fully automatic VITEK 2 COMPACT system. We amplified and sequenced gene fragments of glutamate dehydrogenase and recombination/repair protein and conducted PCR serotyping to confirm some serotypes. Of 71 cases, 44 were confirmed as S. suis; 29 isolates were serotype 2. The average patient age was 48.1 years, and 89% of patients were male. Seventy-seven percent of patients with confirmed cases recovered without complications; 11% recovered with septic shock, 7% with deafness, and 2% with deafness and arthritis. The case-fatality rate was 11%. Awareness of S. suis infection risk must be increased in health promotion activities in Bali. Centers for Disease Control and Prevention 2019-12 /pmc/articles/PMC6874276/ /pubmed/31742523 http://dx.doi.org/10.3201/eid2512.181709 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Susilawathi, Ni Made
Tarini, Ni Made Adi
Fatmawati, Ni Nengah Dwi
Mayura, Putu I.B.
Suryapraba, Anak Agung Ayu
Subrata, Made
Sudewi, Anak Agung Raka
Mahardika, Gusti Ngurah
Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017
title Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017
title_full Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017
title_fullStr Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017
title_full_unstemmed Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017
title_short Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017
title_sort streptococcus suis–associated meningitis, bali, indonesia, 2014–2017
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874276/
https://www.ncbi.nlm.nih.gov/pubmed/31742523
http://dx.doi.org/10.3201/eid2512.181709
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