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Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017
Streptococcus suis is an emerging agent of zoonotic bacterial meningitis in Asia. We describe the epidemiology of S. suis cases and clinical signs and microbiological findings in persons with meningitis in Bali, Indonesia, using patient data and bacterial cultures of cerebrospinal fluid collected du...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874276/ https://www.ncbi.nlm.nih.gov/pubmed/31742523 http://dx.doi.org/10.3201/eid2512.181709 |
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author | Susilawathi, Ni Made Tarini, Ni Made Adi Fatmawati, Ni Nengah Dwi Mayura, Putu I.B. Suryapraba, Anak Agung Ayu Subrata, Made Sudewi, Anak Agung Raka Mahardika, Gusti Ngurah |
author_facet | Susilawathi, Ni Made Tarini, Ni Made Adi Fatmawati, Ni Nengah Dwi Mayura, Putu I.B. Suryapraba, Anak Agung Ayu Subrata, Made Sudewi, Anak Agung Raka Mahardika, Gusti Ngurah |
author_sort | Susilawathi, Ni Made |
collection | PubMed |
description | Streptococcus suis is an emerging agent of zoonotic bacterial meningitis in Asia. We describe the epidemiology of S. suis cases and clinical signs and microbiological findings in persons with meningitis in Bali, Indonesia, using patient data and bacterial cultures of cerebrospinal fluid collected during 2014–2017. We conducted microbiological assays using the fully automatic VITEK 2 COMPACT system. We amplified and sequenced gene fragments of glutamate dehydrogenase and recombination/repair protein and conducted PCR serotyping to confirm some serotypes. Of 71 cases, 44 were confirmed as S. suis; 29 isolates were serotype 2. The average patient age was 48.1 years, and 89% of patients were male. Seventy-seven percent of patients with confirmed cases recovered without complications; 11% recovered with septic shock, 7% with deafness, and 2% with deafness and arthritis. The case-fatality rate was 11%. Awareness of S. suis infection risk must be increased in health promotion activities in Bali. |
format | Online Article Text |
id | pubmed-6874276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-68742762019-12-01 Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017 Susilawathi, Ni Made Tarini, Ni Made Adi Fatmawati, Ni Nengah Dwi Mayura, Putu I.B. Suryapraba, Anak Agung Ayu Subrata, Made Sudewi, Anak Agung Raka Mahardika, Gusti Ngurah Emerg Infect Dis Research Streptococcus suis is an emerging agent of zoonotic bacterial meningitis in Asia. We describe the epidemiology of S. suis cases and clinical signs and microbiological findings in persons with meningitis in Bali, Indonesia, using patient data and bacterial cultures of cerebrospinal fluid collected during 2014–2017. We conducted microbiological assays using the fully automatic VITEK 2 COMPACT system. We amplified and sequenced gene fragments of glutamate dehydrogenase and recombination/repair protein and conducted PCR serotyping to confirm some serotypes. Of 71 cases, 44 were confirmed as S. suis; 29 isolates were serotype 2. The average patient age was 48.1 years, and 89% of patients were male. Seventy-seven percent of patients with confirmed cases recovered without complications; 11% recovered with septic shock, 7% with deafness, and 2% with deafness and arthritis. The case-fatality rate was 11%. Awareness of S. suis infection risk must be increased in health promotion activities in Bali. Centers for Disease Control and Prevention 2019-12 /pmc/articles/PMC6874276/ /pubmed/31742523 http://dx.doi.org/10.3201/eid2512.181709 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Susilawathi, Ni Made Tarini, Ni Made Adi Fatmawati, Ni Nengah Dwi Mayura, Putu I.B. Suryapraba, Anak Agung Ayu Subrata, Made Sudewi, Anak Agung Raka Mahardika, Gusti Ngurah Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017 |
title | Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017 |
title_full | Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017 |
title_fullStr | Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017 |
title_full_unstemmed | Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017 |
title_short | Streptococcus suis–Associated Meningitis, Bali, Indonesia, 2014–2017 |
title_sort | streptococcus suis–associated meningitis, bali, indonesia, 2014–2017 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874276/ https://www.ncbi.nlm.nih.gov/pubmed/31742523 http://dx.doi.org/10.3201/eid2512.181709 |
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