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Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target

An accelerator-based boron neutron capture therapy (BNCT) system that employs a solid-state Li target can achieve sufficient neutron flux derived from the (7)Li(p,n) reaction. However, neutron production is complicated by the large thermal load expected on the target. The relationship between neutro...

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Autores principales: Nakamura, Satoshi, Igaki, Hiroshi, Ito, Masashi, Okamoto, Hiroyuki, Nishioka, Shie, Iijima, Kotaro, Nakayama, Hiroki, Takemori, Mihiro, Imamichi, Shoji, Kashihara, Tairo, Takahashi, Kana, Inaba, Koji, Okuma, Kae, Murakami, Naoya, Abe, Yoshihisa, Nakayama, Yuko, Masutani, Mitsuko, Nishio, Teiji, Itami, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874357/
https://www.ncbi.nlm.nih.gov/pubmed/31756237
http://dx.doi.org/10.1371/journal.pone.0225587
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author Nakamura, Satoshi
Igaki, Hiroshi
Ito, Masashi
Okamoto, Hiroyuki
Nishioka, Shie
Iijima, Kotaro
Nakayama, Hiroki
Takemori, Mihiro
Imamichi, Shoji
Kashihara, Tairo
Takahashi, Kana
Inaba, Koji
Okuma, Kae
Murakami, Naoya
Abe, Yoshihisa
Nakayama, Yuko
Masutani, Mitsuko
Nishio, Teiji
Itami, Jun
author_facet Nakamura, Satoshi
Igaki, Hiroshi
Ito, Masashi
Okamoto, Hiroyuki
Nishioka, Shie
Iijima, Kotaro
Nakayama, Hiroki
Takemori, Mihiro
Imamichi, Shoji
Kashihara, Tairo
Takahashi, Kana
Inaba, Koji
Okuma, Kae
Murakami, Naoya
Abe, Yoshihisa
Nakayama, Yuko
Masutani, Mitsuko
Nishio, Teiji
Itami, Jun
author_sort Nakamura, Satoshi
collection PubMed
description An accelerator-based boron neutron capture therapy (BNCT) system that employs a solid-state Li target can achieve sufficient neutron flux derived from the (7)Li(p,n) reaction. However, neutron production is complicated by the large thermal load expected on the target. The relationship between neutron production and thermal load was examined under various conditions. A target structure for neutron production consists of a Li target and a target basement. Four proton beam profiles were examined to vary the local thermal load on the target structure while maintaining a constant total thermal load. The efficiency of neutron production was evaluated with respect to the total number of protons delivered to the target structure. The target structure was also evaluated by observing its surface after certain numbers of protons were delivered. The yield of the sputtering effect was calculated via a Monte Carlo simulation to investigate whether it caused complications in neutron production. The efficiency of neutron production and the amount of damage done depended on the proton profile. A more focused proton profile resulted in greater damage. The efficiency decreased as the total number of protons delivered to the target structure increased, and the rate of decrease depended on the proton profile. The sputtering effect was not sufficiently large to be a main factor in the reduction in neutron production. The proton beam profile on the target structure was found to be important to the stable operation of the system with a solid-state Li target. The main factor in the rate of reduction in neutron production was found to be the local thermal load induced by proton irradiation of the target.
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spelling pubmed-68743572019-12-06 Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target Nakamura, Satoshi Igaki, Hiroshi Ito, Masashi Okamoto, Hiroyuki Nishioka, Shie Iijima, Kotaro Nakayama, Hiroki Takemori, Mihiro Imamichi, Shoji Kashihara, Tairo Takahashi, Kana Inaba, Koji Okuma, Kae Murakami, Naoya Abe, Yoshihisa Nakayama, Yuko Masutani, Mitsuko Nishio, Teiji Itami, Jun PLoS One Research Article An accelerator-based boron neutron capture therapy (BNCT) system that employs a solid-state Li target can achieve sufficient neutron flux derived from the (7)Li(p,n) reaction. However, neutron production is complicated by the large thermal load expected on the target. The relationship between neutron production and thermal load was examined under various conditions. A target structure for neutron production consists of a Li target and a target basement. Four proton beam profiles were examined to vary the local thermal load on the target structure while maintaining a constant total thermal load. The efficiency of neutron production was evaluated with respect to the total number of protons delivered to the target structure. The target structure was also evaluated by observing its surface after certain numbers of protons were delivered. The yield of the sputtering effect was calculated via a Monte Carlo simulation to investigate whether it caused complications in neutron production. The efficiency of neutron production and the amount of damage done depended on the proton profile. A more focused proton profile resulted in greater damage. The efficiency decreased as the total number of protons delivered to the target structure increased, and the rate of decrease depended on the proton profile. The sputtering effect was not sufficiently large to be a main factor in the reduction in neutron production. The proton beam profile on the target structure was found to be important to the stable operation of the system with a solid-state Li target. The main factor in the rate of reduction in neutron production was found to be the local thermal load induced by proton irradiation of the target. Public Library of Science 2019-11-22 /pmc/articles/PMC6874357/ /pubmed/31756237 http://dx.doi.org/10.1371/journal.pone.0225587 Text en © 2019 Nakamura et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nakamura, Satoshi
Igaki, Hiroshi
Ito, Masashi
Okamoto, Hiroyuki
Nishioka, Shie
Iijima, Kotaro
Nakayama, Hiroki
Takemori, Mihiro
Imamichi, Shoji
Kashihara, Tairo
Takahashi, Kana
Inaba, Koji
Okuma, Kae
Murakami, Naoya
Abe, Yoshihisa
Nakayama, Yuko
Masutani, Mitsuko
Nishio, Teiji
Itami, Jun
Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
title Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
title_full Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
title_fullStr Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
title_full_unstemmed Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
title_short Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
title_sort characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state li target
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874357/
https://www.ncbi.nlm.nih.gov/pubmed/31756237
http://dx.doi.org/10.1371/journal.pone.0225587
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