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Electric field causes volumetric changes in the human brain

Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determ...

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Autores principales: Argyelan, Miklos, Oltedal, Leif, Deng, Zhi-De, Wade, Benjamin, Bikson, Marom, Joanlanne, Andrea, Sanghani, Sohag, Bartsch, Hauke, Cano, Marta, Dale, Anders M, Dannlowski, Udo, Dols, Annemiek, Enneking, Verena, Espinoza, Randall, Kessler, Ute, Narr, Katherine L, Oedegaard, Ketil J, Oudega, Mardien L, Redlich, Ronny, Stek, Max L, Takamiya, Akihiro, Emsell, Louise, Bouckaert, Filip, Sienaert, Pascal, Pujol, Jesus, Tendolkar, Indira, van Eijndhoven, Philip, Petrides, Georgios, Malhotra, Anil K, Abbott, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874416/
https://www.ncbi.nlm.nih.gov/pubmed/31644424
http://dx.doi.org/10.7554/eLife.49115
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author Argyelan, Miklos
Oltedal, Leif
Deng, Zhi-De
Wade, Benjamin
Bikson, Marom
Joanlanne, Andrea
Sanghani, Sohag
Bartsch, Hauke
Cano, Marta
Dale, Anders M
Dannlowski, Udo
Dols, Annemiek
Enneking, Verena
Espinoza, Randall
Kessler, Ute
Narr, Katherine L
Oedegaard, Ketil J
Oudega, Mardien L
Redlich, Ronny
Stek, Max L
Takamiya, Akihiro
Emsell, Louise
Bouckaert, Filip
Sienaert, Pascal
Pujol, Jesus
Tendolkar, Indira
van Eijndhoven, Philip
Petrides, Georgios
Malhotra, Anil K
Abbott, Christopher
author_facet Argyelan, Miklos
Oltedal, Leif
Deng, Zhi-De
Wade, Benjamin
Bikson, Marom
Joanlanne, Andrea
Sanghani, Sohag
Bartsch, Hauke
Cano, Marta
Dale, Anders M
Dannlowski, Udo
Dols, Annemiek
Enneking, Verena
Espinoza, Randall
Kessler, Ute
Narr, Katherine L
Oedegaard, Ketil J
Oudega, Mardien L
Redlich, Ronny
Stek, Max L
Takamiya, Akihiro
Emsell, Louise
Bouckaert, Filip
Sienaert, Pascal
Pujol, Jesus
Tendolkar, Indira
van Eijndhoven, Philip
Petrides, Georgios
Malhotra, Anil K
Abbott, Christopher
author_sort Argyelan, Miklos
collection PubMed
description Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.
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spelling pubmed-68744162019-11-23 Electric field causes volumetric changes in the human brain Argyelan, Miklos Oltedal, Leif Deng, Zhi-De Wade, Benjamin Bikson, Marom Joanlanne, Andrea Sanghani, Sohag Bartsch, Hauke Cano, Marta Dale, Anders M Dannlowski, Udo Dols, Annemiek Enneking, Verena Espinoza, Randall Kessler, Ute Narr, Katherine L Oedegaard, Ketil J Oudega, Mardien L Redlich, Ronny Stek, Max L Takamiya, Akihiro Emsell, Louise Bouckaert, Filip Sienaert, Pascal Pujol, Jesus Tendolkar, Indira van Eijndhoven, Philip Petrides, Georgios Malhotra, Anil K Abbott, Christopher eLife Human Biology and Medicine Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion. eLife Sciences Publications, Ltd 2019-10-23 /pmc/articles/PMC6874416/ /pubmed/31644424 http://dx.doi.org/10.7554/eLife.49115 Text en http://creativecommons.org/publicdomain/zero/1.0/ http://creativecommons.org/publicdomain/zero/1.0/This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication (http://creativecommons.org/publicdomain/zero/1.0/) .
spellingShingle Human Biology and Medicine
Argyelan, Miklos
Oltedal, Leif
Deng, Zhi-De
Wade, Benjamin
Bikson, Marom
Joanlanne, Andrea
Sanghani, Sohag
Bartsch, Hauke
Cano, Marta
Dale, Anders M
Dannlowski, Udo
Dols, Annemiek
Enneking, Verena
Espinoza, Randall
Kessler, Ute
Narr, Katherine L
Oedegaard, Ketil J
Oudega, Mardien L
Redlich, Ronny
Stek, Max L
Takamiya, Akihiro
Emsell, Louise
Bouckaert, Filip
Sienaert, Pascal
Pujol, Jesus
Tendolkar, Indira
van Eijndhoven, Philip
Petrides, Georgios
Malhotra, Anil K
Abbott, Christopher
Electric field causes volumetric changes in the human brain
title Electric field causes volumetric changes in the human brain
title_full Electric field causes volumetric changes in the human brain
title_fullStr Electric field causes volumetric changes in the human brain
title_full_unstemmed Electric field causes volumetric changes in the human brain
title_short Electric field causes volumetric changes in the human brain
title_sort electric field causes volumetric changes in the human brain
topic Human Biology and Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874416/
https://www.ncbi.nlm.nih.gov/pubmed/31644424
http://dx.doi.org/10.7554/eLife.49115
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