LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p

The transcript factor LHX2 is dysregulated in many cancers but its role in osteosarcoma (OS) remains unclear. In this study, we confirm that LHX2 is up-regulated in osteosarcoma, and that its silencing inhibits OS malignancy and induces autophagy via mTOR signaling. We further demonstrate that miR-1...

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Autores principales: Song, Honghai, Liu, Jiaming, Wu, Xin, Zhou, Yang, Chen, Xuanyin, Chen, Jiangwei, Deng, Keyu, Mao, Chunxia, Huang, Shanhu, Liu, Zhili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874432/
https://www.ncbi.nlm.nih.gov/pubmed/31724536
http://dx.doi.org/10.18632/aging.102427
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author Song, Honghai
Liu, Jiaming
Wu, Xin
Zhou, Yang
Chen, Xuanyin
Chen, Jiangwei
Deng, Keyu
Mao, Chunxia
Huang, Shanhu
Liu, Zhili
author_facet Song, Honghai
Liu, Jiaming
Wu, Xin
Zhou, Yang
Chen, Xuanyin
Chen, Jiangwei
Deng, Keyu
Mao, Chunxia
Huang, Shanhu
Liu, Zhili
author_sort Song, Honghai
collection PubMed
description The transcript factor LHX2 is dysregulated in many cancers but its role in osteosarcoma (OS) remains unclear. In this study, we confirm that LHX2 is up-regulated in osteosarcoma, and that its silencing inhibits OS malignancy and induces autophagy via mTOR signaling. We further demonstrate that miR-129-5p negatively regulates LHX2 and suppresses the malignant phenotypes of OS. LHX2 overexpression could restore the malignant phenotypes. In conclusion, LHX2 regulates tumorigenesis and autophagy via mTOR in OS and is negatively regulated by miR-129-5p. Targeting the miR-129-5p/LHX2/mTOR axis therefore represents a novel therapeutic strategy for OS treatment.
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spelling pubmed-68744322019-12-03 LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p Song, Honghai Liu, Jiaming Wu, Xin Zhou, Yang Chen, Xuanyin Chen, Jiangwei Deng, Keyu Mao, Chunxia Huang, Shanhu Liu, Zhili Aging (Albany NY) Research Paper The transcript factor LHX2 is dysregulated in many cancers but its role in osteosarcoma (OS) remains unclear. In this study, we confirm that LHX2 is up-regulated in osteosarcoma, and that its silencing inhibits OS malignancy and induces autophagy via mTOR signaling. We further demonstrate that miR-129-5p negatively regulates LHX2 and suppresses the malignant phenotypes of OS. LHX2 overexpression could restore the malignant phenotypes. In conclusion, LHX2 regulates tumorigenesis and autophagy via mTOR in OS and is negatively regulated by miR-129-5p. Targeting the miR-129-5p/LHX2/mTOR axis therefore represents a novel therapeutic strategy for OS treatment. Impact Journals 2019-11-13 /pmc/articles/PMC6874432/ /pubmed/31724536 http://dx.doi.org/10.18632/aging.102427 Text en Copyright © 2019 Song et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Song, Honghai
Liu, Jiaming
Wu, Xin
Zhou, Yang
Chen, Xuanyin
Chen, Jiangwei
Deng, Keyu
Mao, Chunxia
Huang, Shanhu
Liu, Zhili
LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p
title LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p
title_full LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p
title_fullStr LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p
title_full_unstemmed LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p
title_short LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p
title_sort lhx2 promotes malignancy and inhibits autophagy via mtor in osteosarcoma and is negatively regulated by mir-129-5p
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874432/
https://www.ncbi.nlm.nih.gov/pubmed/31724536
http://dx.doi.org/10.18632/aging.102427
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