LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p

The transcript factor LHX2 is dysregulated in many cancers but its role in osteosarcoma (OS) remains unclear. In this study, we confirm that LHX2 is up-regulated in osteosarcoma, and that its silencing inhibits OS malignancy and induces autophagy via mTOR signaling. We further demonstrate that miR-1...

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Detalles Bibliográficos
Autores principales: Song, Honghai, Liu, Jiaming, Wu, Xin, Zhou, Yang, Chen, Xuanyin, Chen, Jiangwei, Deng, Keyu, Mao, Chunxia, Huang, Shanhu, Liu, Zhili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874432/
https://www.ncbi.nlm.nih.gov/pubmed/31724536
http://dx.doi.org/10.18632/aging.102427

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