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Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury

Dexmedetomidine is known to alleviate cerebral ischemia-reperfusion injury (CIRI). We established a rat model of CIRI, which exhibited higher neurological deficit scores and a greater number of apoptotic cells in the cerebral ischemic penumbra than controls. Dexmedetomidine reversed the neuronal apo...

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Detalles Bibliográficos
Autores principales:	Zhai, Meili, Liu, Chong, Li, Yuexiang, Zhang, Peijun, Yu, Zhiqiang, Zhu, He, Zhang, Li, Zhang, Qian, Wang, Jianbo, Wang, Jinhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874446/ https://www.ncbi.nlm.nih.gov/pubmed/31682592 http://dx.doi.org/10.18632/aging.102404

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