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Resurrection of ancestral effector caspases identifies novel networks for evolution of substrate specificity

Apoptotic caspases evolved with metazoans more than 950 million years ago (MYA), and a series of gene duplications resulted in two subfamilies consisting of initiator and effector caspases. The effector caspase genes (caspases-3, -6, and -7) were subsequently fixed into the Chordata phylum more than...

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Detalles Bibliográficos
Autores principales:	Grinshpon, Robert D., Shrestha, Suman, Titus-McQuillan, James, Hamilton, Paul T., Swartz, Paul D., Clark, A. Clay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2019
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874516/ https://www.ncbi.nlm.nih.gov/pubmed/31675069 http://dx.doi.org/10.1042/BCJ20190625

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