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Sorsby Fundus Dystrophy Mutation in Tissue Inhibitor of Metalloproteinase 3 (TIMP3) promotes Choroidal Neovascularization via a Fibroblast Growth Factor-dependent Mechanism

Choroidal neovascularization (CNV) leads to loss of vision in patients with Sorsby Fundus Dystrophy (SFD), an inherited, macular degenerative disorder, caused by mutations in the Tissue Inhibitor of Metalloproteinase-3 (TIMP3) gene. SFD closely resembles age-related macular degeneration (AMD), which...

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Detalles Bibliográficos
Autores principales:	Qi, Jian Hua, Bell, Brent, Singh, Rupesh, Batoki, Julia, Wolk, Alyson, Cutler, Alecia, Prayson, Nicholas, Ali, Mariya, Stoehr, Heidi, Anand-Apte, Bela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874529/ https://www.ncbi.nlm.nih.gov/pubmed/31757977 http://dx.doi.org/10.1038/s41598-019-53433-6

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