Cargando…

Sorsby Fundus Dystrophy Mutation in Tissue Inhibitor of Metalloproteinase 3 (TIMP3) promotes Choroidal Neovascularization via a Fibroblast Growth Factor-dependent Mechanism

Choroidal neovascularization (CNV) leads to loss of vision in patients with Sorsby Fundus Dystrophy (SFD), an inherited, macular degenerative disorder, caused by mutations in the Tissue Inhibitor of Metalloproteinase-3 (TIMP3) gene. SFD closely resembles age-related macular degeneration (AMD), which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qi, Jian Hua, Bell, Brent, Singh, Rupesh, Batoki, Julia, Wolk, Alyson, Cutler, Alecia, Prayson, Nicholas, Ali, Mariya, Stoehr, Heidi, Anand-Apte, Bela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874529/ https://www.ncbi.nlm.nih.gov/pubmed/31757977 http://dx.doi.org/10.1038/s41598-019-53433-6

Ejemplares similares

Role of FGF and Hyaluronan in Choroidal Neovascularization in Sorsby Fundus Dystrophy
por: Wolk, Alyson, et al.
Publicado: (2020)

The retinal pigment epithelium in Sorsby Fundus Dystrophy shows increased sensitivity to oxidative stress-induced degeneration
por: Wolk, Alyson, et al.
Publicado: (2020)

Tissue Inhibitor of Metalloproteinases-3 Peptides Inhibit Angiogenesis and Choroidal Neovascularization in Mice
por: Qi, Jian Hua, et al.
Publicado: (2013)

Deglycosylation Increases the Aggregation and Angiogenic Properties of Mutant Tissue Inhibitor of Metalloproteinase 3 Protein: Implications for Sorsby Fundus Dystrophy
por: Qi, Jian Hua, et al.
Publicado: (2022)

OCT angiography in the management of choroidal neovascular membrane secondary to Sorsby fundus dystrophy
por: Mohla, Aditi, et al.
Publicado: (2016)

Clinical and biochemical effects of the E139K missense mutation in the TIMP3 gene, associated with Sorsby fundus dystrophy
por: Saihan, Z., et al.
Publicado: (2009)

Sorsby fundus dystrophy (SFD): A narrative review
por: Tsokolas, Georgios
Publicado: (2022)

The N‐terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond
por: Naessens, Sarah, et al.
Publicado: (2019)

Potential CRISPR Base Editing Therapeutic Options in a Sorsby Fundus Dystrophy Patient
por: Elsayed, Maram E. A. Abdalla, et al.
Publicado: (2022)

Can Novel Treatment of Age-Related Macular Degeneration Be Developed by Better Understanding of Sorsby’s Fundus Dystrophy
por: Gourier, Hanae C. Y., et al.
Publicado: (2015)

Visual Outcome after Intravitreal Anti-VEGF Therapy for Macular Neovascularisation Secondary to Sorsby’s Fundus Dystrophy: A Systematic Review
por: Baston, Arthur, et al.
Publicado: (2021)

Key Role of Microglial Matrix Metalloproteinases in Choroidal Neovascularization
por: Kim, Juhee, et al.
Publicado: (2021)

Matrix Metalloproteinase 13 Is Associated with Age-Related Choroidal Neovascularization
por: González-Zamora, Jorge, et al.
Publicado: (2023)

CCR3 and Choroidal Neovascularization
por: Li, Yiwen, et al.
Publicado: (2011)

Efficacy of anti-VEGF in the treatment of choroidal neovascular membrane secondary to pattern dystrophy simulating fundus flavimaculatus
por: Nangia, Purna, et al.
Publicado: (2019)

Changes in VEGF-related factors are associated with presence of inflammatory factors in carbohydrate metabolism disorders during pregnancy
por: Sugimoto, Masahiko, et al.
Publicado: (2019)

Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) Regulates Hematopoiesis and Bone Formation In Vivo
por: Shen, Yi, et al.
Publicado: (2010)

Deep Learning Algorithm Detects Presence of Disorganization of Retinal Inner Layers (DRIL)–An Early Imaging Biomarker in Diabetic Retinopathy
por: Singh, Rupesh, et al.
Publicado: (2023)

Spectral domain-optical coherence tomography retinal biomarkers in choroidal neovascularization of multifocal choroiditis, myopic choroidal neovascularization, and idiopathic choroidal neovascularization
por: Gao, Rui, et al.
Publicado: (2021)

Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular Pathology
por: Fan, Dong, et al.
Publicado: (2020)

Assessment of prognostic value of tissue inhibitors of metalloproteinase 3 (TIMP3) protein in ovarian cancer
por: Hakamy, Sahar, et al.
Publicado: (2021)

Mesopic and Dark-Adapted Two-Color Fundus-Controlled Perimetry in Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
por: von der Emde, Leon, et al.
Publicado: (2018)

Inflammatory Choroidal Neovascularization
por: Neri, Piergiorgi, et al.
Publicado: (2009)

Expression of collagenases (matrix metalloproteinase-1, -8, -13) and tissue inhibitor of metalloproteinase-3 (TIMP-3) in naturally occurring bovine cutaneous fibropapillomas
por: Daraban Bocaneti, Florentina, et al.
Publicado: (2023)

An update on inflammatory choroidal neovascularization: epidemiology, multimodal imaging, and management
por: Agarwal, Aniruddha, et al.
Publicado: (2018)

Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma.
por: Joo, Y. E., et al.
Publicado: (1999)

Expression of Tissue Inhibitors of Metalloproteinases (TIMPs) in Hepatocellular Carcinoma
por: Joo, Young-Eun, et al.
Publicado: (2000)

The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP-3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis
por: Łanocha-Arendarczyk, Natalia, et al.
Publicado: (2018)

Changes in Gene and Protein Expression of Metalloproteinase-2 and -9 and Their Inhibitors TIMP2 and TIMP3 in Different Parts of Fluoride-Exposed Rat Brain
por: Łukomska, Agnieszka, et al.
Publicado: (2020)

Fundus Autofluorescence Imaging in Patients with Choroidal Melanoma
por: Bindewald-Wittich, Almut, et al.
Publicado: (2022)

Laser-Induced Choroidal Neovascularizations: Clinical Study of 3 Cases
por: Laovirojjanakul, Wipada, et al.
Publicado: (2017)

Bilateral Multifocal Choroidal Osteoma with Choroidal Neovascularization
por: MirNaghi, Mousavi, et al.
Publicado: (2015)

Balance between matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in the cervical mucus plug estimated by determination of free non-complexed TIMP
por: Becher, Naja, et al.
Publicado: (2008)

Differential effects of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 on atherosclerosis and monocyte/macrophage invasion
por: Di Gregoli, Karina, et al.
Publicado: (2016)

Changes in Fundus Autofluorescence after Anti-vascular Endothelial Growth Factor According to the Type of Choroidal Neovascularization in Age-related Macular Degeneration
por: Lee, Ji Young, et al.
Publicado: (2016)

STAT3-mediated activation of miR-21 is involved in down-regulation of TIMP3 and neovascularization in the ischemic retina
por: Gutsaeva, Diana R., et al.
Publicado: (2017)

Is Asthma Related to Choroidal Neovascularization?
por: Sun, Yaoyao, et al.
Publicado: (2012)

Choroidal neovascular membrane in a treated choroidal hemangioma
por: Nagesha, Chokkahalli K, et al.
Publicado: (2016)

Choroidal Osteoma and Secondary Choroidal Neovascularization Treated with Ranibizumab
por: Sarıgül Sezenöz, Almila, et al.
Publicado: (2017)

Gene Expression of Matrix Metalloproteinases and their Inhibitors (TIMPs) in Meningiomas of Dogs
por: Mandara, M.T., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_2kvltfm76fu7s6616d9p1vcuvm