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Early life home microbiome and hyperactivity/inattention in school-age children
This study evaluates the association between indoor microbial diversity early in life and hyperactivity/inattention symptoms in children at ages 10 and 15 years.A random sample enriched with subjects with hyperactivity/inattention at age 15 years was selected from the German LISA birth cohort. Bedro...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874766/ https://www.ncbi.nlm.nih.gov/pubmed/31758010 http://dx.doi.org/10.1038/s41598-019-53527-1 |
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author | Casas, Lidia Karvonen, Anne M. Kirjavainen, Pirkka V. Täubel, Martin Hyytiäinen, Heidi Jayaprakash, Balamuralikrishna Lehmann, Irina Standl, Marie Pekkanen, Juha Heinrich, Joachim |
author_facet | Casas, Lidia Karvonen, Anne M. Kirjavainen, Pirkka V. Täubel, Martin Hyytiäinen, Heidi Jayaprakash, Balamuralikrishna Lehmann, Irina Standl, Marie Pekkanen, Juha Heinrich, Joachim |
author_sort | Casas, Lidia |
collection | PubMed |
description | This study evaluates the association between indoor microbial diversity early in life and hyperactivity/inattention symptoms in children at ages 10 and 15 years.A random sample enriched with subjects with hyperactivity/inattention at age 15 years was selected from the German LISA birth cohort. Bedroom floor dust was collected at age 3 months and 4 bacterial and fungal diversity measures [number of observed operational taxonomic units (OTUs), Chao1, Shannon and Simpson indices] were calculated from Illumina MiSeq sequencing data. Hyperactivity/inattention was based on the Strengths and Difficulties Questionnaire at ages 10 and 15 (cut-off ≥7). Adjusted associations between 4 diversity measures in tertiles and hyperactivity/inattention were investigated with weighted and survey logistic regression models. We included 226 individuals with information on microbial diversity and hyperactivity/inattention. Early life bacterial diversity was inversely associated with hyperactivity/inattention at age 10 [bacterial OTUs (medium vs low: aOR = 0.4, 95%CI = (0.2–0.8)) and Chao1 (medium vs low: 0.3 (0.1–0.5); high vs low: 0.3 (0.2–0.6)], whereas fungal diversity was directly associated [Chao1 (high vs low: 2.1 (1.1–4.0)), Shannon (medium vs low: 2.8 (1.3–5.8)), and Simpson (medium vs low: 4.7 (2.4–9.3))]. At age 15, only Shannon index was significantly associated with hyperactivity/inattention [bacteria (medium vs low: 2.3 (1.2–4.2); fungi (high vs low: 0.5 (0.3–0.9))]. In conclusion, early life exposure to microbial diversity may play a role in the psychobehavioural development. We observe heterogeneity in the direction of the associations encouraging further longitudinal studies to deepen our understanding of the characteristics of the microbial community underlying the observed associations. |
format | Online Article Text |
id | pubmed-6874766 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68747662019-12-04 Early life home microbiome and hyperactivity/inattention in school-age children Casas, Lidia Karvonen, Anne M. Kirjavainen, Pirkka V. Täubel, Martin Hyytiäinen, Heidi Jayaprakash, Balamuralikrishna Lehmann, Irina Standl, Marie Pekkanen, Juha Heinrich, Joachim Sci Rep Article This study evaluates the association between indoor microbial diversity early in life and hyperactivity/inattention symptoms in children at ages 10 and 15 years.A random sample enriched with subjects with hyperactivity/inattention at age 15 years was selected from the German LISA birth cohort. Bedroom floor dust was collected at age 3 months and 4 bacterial and fungal diversity measures [number of observed operational taxonomic units (OTUs), Chao1, Shannon and Simpson indices] were calculated from Illumina MiSeq sequencing data. Hyperactivity/inattention was based on the Strengths and Difficulties Questionnaire at ages 10 and 15 (cut-off ≥7). Adjusted associations between 4 diversity measures in tertiles and hyperactivity/inattention were investigated with weighted and survey logistic regression models. We included 226 individuals with information on microbial diversity and hyperactivity/inattention. Early life bacterial diversity was inversely associated with hyperactivity/inattention at age 10 [bacterial OTUs (medium vs low: aOR = 0.4, 95%CI = (0.2–0.8)) and Chao1 (medium vs low: 0.3 (0.1–0.5); high vs low: 0.3 (0.2–0.6)], whereas fungal diversity was directly associated [Chao1 (high vs low: 2.1 (1.1–4.0)), Shannon (medium vs low: 2.8 (1.3–5.8)), and Simpson (medium vs low: 4.7 (2.4–9.3))]. At age 15, only Shannon index was significantly associated with hyperactivity/inattention [bacteria (medium vs low: 2.3 (1.2–4.2); fungi (high vs low: 0.5 (0.3–0.9))]. In conclusion, early life exposure to microbial diversity may play a role in the psychobehavioural development. We observe heterogeneity in the direction of the associations encouraging further longitudinal studies to deepen our understanding of the characteristics of the microbial community underlying the observed associations. Nature Publishing Group UK 2019-11-22 /pmc/articles/PMC6874766/ /pubmed/31758010 http://dx.doi.org/10.1038/s41598-019-53527-1 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Casas, Lidia Karvonen, Anne M. Kirjavainen, Pirkka V. Täubel, Martin Hyytiäinen, Heidi Jayaprakash, Balamuralikrishna Lehmann, Irina Standl, Marie Pekkanen, Juha Heinrich, Joachim Early life home microbiome and hyperactivity/inattention in school-age children |
title | Early life home microbiome and hyperactivity/inattention in school-age children |
title_full | Early life home microbiome and hyperactivity/inattention in school-age children |
title_fullStr | Early life home microbiome and hyperactivity/inattention in school-age children |
title_full_unstemmed | Early life home microbiome and hyperactivity/inattention in school-age children |
title_short | Early life home microbiome and hyperactivity/inattention in school-age children |
title_sort | early life home microbiome and hyperactivity/inattention in school-age children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874766/ https://www.ncbi.nlm.nih.gov/pubmed/31758010 http://dx.doi.org/10.1038/s41598-019-53527-1 |
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