Cargando…
Hypermethylated KLF9 Is An Independent Prognostic Factor For Favorable Outcome In Breast Cancer
BACKGROUND AND OBJECTIVE: Breast cancer (BC) is the most lethal human malignancy and is the leading cause of cancer-associated death in women worldwide. Krüppel-like factor 9 (KLF9) belongs to a family of transcriptional regulators and its role in BC has not been fully investigated. METHOD: Data min...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874775/ https://www.ncbi.nlm.nih.gov/pubmed/31819488 http://dx.doi.org/10.2147/OTT.S226121 |
_version_ | 1783472892393029632 |
---|---|
author | Wang, Lei Mao, Qiqi Zhou, Shaocheng Ji, Xiaochun |
author_facet | Wang, Lei Mao, Qiqi Zhou, Shaocheng Ji, Xiaochun |
author_sort | Wang, Lei |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Breast cancer (BC) is the most lethal human malignancy and is the leading cause of cancer-associated death in women worldwide. Krüppel-like factor 9 (KLF9) belongs to a family of transcriptional regulators and its role in BC has not been fully investigated. METHOD: Data mining was used to analyze BC data from The Cancer Genome Atlas (TCGA) database, which was downloaded using the UCSC Xena browser. The differential expression and methylation level of KLF9 was analyzed in patients with BC and corresponding normal controls enrolled from our hospital. Besides, the correlation of KLF9 methylation and prognosis was explored, and gene set enrichment analysis (GSEA) was conducted to identify the potential signaling pathway of KLF9 involved. RESULTS: Both TCGA and BC tissues indicated hypermethylation of the KLF9 promoter region in patients with BC compared with normal controls, which might account for the dysregulation of KLF9 in patients with BC. Besides, hypermethylation of KLF9 was detected in patients with estrogen or progesterone receptor-positive and non-triple-negative disease. Further, hypermethylation of KLF9 was demonstrated to be a potential independent biomarker in obtaining favorable outcomes in BC. By GSEA, tumor-associated biological processes and signaling pathway were identified, which indicated that KLF9 might play a vital role in the carcinogenesis of BC. CONCLUSION: KFL9 plays an important role in the carcinogenesis of BC through the multiple tumor-associated signaling pathway. The hypermethylation of KLF9 resulted in its reduced expression in BC, while the hypermethylation of KLF9 has potential in the prediction of favorable outcomes in BC. |
format | Online Article Text |
id | pubmed-6874775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-68747752019-12-09 Hypermethylated KLF9 Is An Independent Prognostic Factor For Favorable Outcome In Breast Cancer Wang, Lei Mao, Qiqi Zhou, Shaocheng Ji, Xiaochun Onco Targets Ther Original Research BACKGROUND AND OBJECTIVE: Breast cancer (BC) is the most lethal human malignancy and is the leading cause of cancer-associated death in women worldwide. Krüppel-like factor 9 (KLF9) belongs to a family of transcriptional regulators and its role in BC has not been fully investigated. METHOD: Data mining was used to analyze BC data from The Cancer Genome Atlas (TCGA) database, which was downloaded using the UCSC Xena browser. The differential expression and methylation level of KLF9 was analyzed in patients with BC and corresponding normal controls enrolled from our hospital. Besides, the correlation of KLF9 methylation and prognosis was explored, and gene set enrichment analysis (GSEA) was conducted to identify the potential signaling pathway of KLF9 involved. RESULTS: Both TCGA and BC tissues indicated hypermethylation of the KLF9 promoter region in patients with BC compared with normal controls, which might account for the dysregulation of KLF9 in patients with BC. Besides, hypermethylation of KLF9 was detected in patients with estrogen or progesterone receptor-positive and non-triple-negative disease. Further, hypermethylation of KLF9 was demonstrated to be a potential independent biomarker in obtaining favorable outcomes in BC. By GSEA, tumor-associated biological processes and signaling pathway were identified, which indicated that KLF9 might play a vital role in the carcinogenesis of BC. CONCLUSION: KFL9 plays an important role in the carcinogenesis of BC through the multiple tumor-associated signaling pathway. The hypermethylation of KLF9 resulted in its reduced expression in BC, while the hypermethylation of KLF9 has potential in the prediction of favorable outcomes in BC. Dove 2019-11-18 /pmc/articles/PMC6874775/ /pubmed/31819488 http://dx.doi.org/10.2147/OTT.S226121 Text en © 2019 Wang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Wang, Lei Mao, Qiqi Zhou, Shaocheng Ji, Xiaochun Hypermethylated KLF9 Is An Independent Prognostic Factor For Favorable Outcome In Breast Cancer |
title | Hypermethylated KLF9 Is An Independent Prognostic Factor For Favorable Outcome In Breast Cancer |
title_full | Hypermethylated KLF9 Is An Independent Prognostic Factor For Favorable Outcome In Breast Cancer |
title_fullStr | Hypermethylated KLF9 Is An Independent Prognostic Factor For Favorable Outcome In Breast Cancer |
title_full_unstemmed | Hypermethylated KLF9 Is An Independent Prognostic Factor For Favorable Outcome In Breast Cancer |
title_short | Hypermethylated KLF9 Is An Independent Prognostic Factor For Favorable Outcome In Breast Cancer |
title_sort | hypermethylated klf9 is an independent prognostic factor for favorable outcome in breast cancer |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874775/ https://www.ncbi.nlm.nih.gov/pubmed/31819488 http://dx.doi.org/10.2147/OTT.S226121 |
work_keys_str_mv | AT wanglei hypermethylatedklf9isanindependentprognosticfactorforfavorableoutcomeinbreastcancer AT maoqiqi hypermethylatedklf9isanindependentprognosticfactorforfavorableoutcomeinbreastcancer AT zhoushaocheng hypermethylatedklf9isanindependentprognosticfactorforfavorableoutcomeinbreastcancer AT jixiaochun hypermethylatedklf9isanindependentprognosticfactorforfavorableoutcomeinbreastcancer |