The interplay between m6A RNA methylation and noncoding RNA in cancer

N6-methyladenosine (m6A) methylation, one of the most common RNA modifications, has been reported to execute important functions that affect normal life activities and diseases. Most studies have suggested that m6A modification can affect the complexity of cancer progression by regulating biological...

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Autores principales: Ma, Shuai, Chen, Chen, Ji, Xiang, Liu, Jinbo, Zhou, Quanbo, Wang, Guixian, Yuan, Weitang, Kan, Quancheng, Sun, Zhenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874823/
https://www.ncbi.nlm.nih.gov/pubmed/31757221
http://dx.doi.org/10.1186/s13045-019-0805-7
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author Ma, Shuai
Chen, Chen
Ji, Xiang
Liu, Jinbo
Zhou, Quanbo
Wang, Guixian
Yuan, Weitang
Kan, Quancheng
Sun, Zhenqiang
author_facet Ma, Shuai
Chen, Chen
Ji, Xiang
Liu, Jinbo
Zhou, Quanbo
Wang, Guixian
Yuan, Weitang
Kan, Quancheng
Sun, Zhenqiang
author_sort Ma, Shuai
collection PubMed
description N6-methyladenosine (m6A) methylation, one of the most common RNA modifications, has been reported to execute important functions that affect normal life activities and diseases. Most studies have suggested that m6A modification can affect the complexity of cancer progression by regulating biological functions related to cancer. M6A modification of noncoding RNAs regulates the cleavage, transport, stability, and degradation of noncoding RNAs themselves. It also regulates cell proliferation and metastasis, stem cell differentiation, and homeostasis in cancer by affecting the biological function of cells. Interestingly, noncoding RNAs also play significant roles in regulating these m6A modifications. Additionally, it is becoming increasingly clear that m6A and noncoding RNAs potentially contribute to the clinical application of cancer treatment. In this review, we summarize the effect of the interactions between m6A modifications and noncoding RNAs on the biological functions involved in cancer progression. In particular, we discuss the role of m6A and noncoding RNAs as possible potential biomarkers and therapeutic targets in the treatment of cancers.
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spelling pubmed-68748232019-11-25 The interplay between m6A RNA methylation and noncoding RNA in cancer Ma, Shuai Chen, Chen Ji, Xiang Liu, Jinbo Zhou, Quanbo Wang, Guixian Yuan, Weitang Kan, Quancheng Sun, Zhenqiang J Hematol Oncol Review N6-methyladenosine (m6A) methylation, one of the most common RNA modifications, has been reported to execute important functions that affect normal life activities and diseases. Most studies have suggested that m6A modification can affect the complexity of cancer progression by regulating biological functions related to cancer. M6A modification of noncoding RNAs regulates the cleavage, transport, stability, and degradation of noncoding RNAs themselves. It also regulates cell proliferation and metastasis, stem cell differentiation, and homeostasis in cancer by affecting the biological function of cells. Interestingly, noncoding RNAs also play significant roles in regulating these m6A modifications. Additionally, it is becoming increasingly clear that m6A and noncoding RNAs potentially contribute to the clinical application of cancer treatment. In this review, we summarize the effect of the interactions between m6A modifications and noncoding RNAs on the biological functions involved in cancer progression. In particular, we discuss the role of m6A and noncoding RNAs as possible potential biomarkers and therapeutic targets in the treatment of cancers. BioMed Central 2019-11-22 /pmc/articles/PMC6874823/ /pubmed/31757221 http://dx.doi.org/10.1186/s13045-019-0805-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Ma, Shuai
Chen, Chen
Ji, Xiang
Liu, Jinbo
Zhou, Quanbo
Wang, Guixian
Yuan, Weitang
Kan, Quancheng
Sun, Zhenqiang
The interplay between m6A RNA methylation and noncoding RNA in cancer
title The interplay between m6A RNA methylation and noncoding RNA in cancer
title_full The interplay between m6A RNA methylation and noncoding RNA in cancer
title_fullStr The interplay between m6A RNA methylation and noncoding RNA in cancer
title_full_unstemmed The interplay between m6A RNA methylation and noncoding RNA in cancer
title_short The interplay between m6A RNA methylation and noncoding RNA in cancer
title_sort interplay between m6a rna methylation and noncoding rna in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874823/
https://www.ncbi.nlm.nih.gov/pubmed/31757221
http://dx.doi.org/10.1186/s13045-019-0805-7
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