Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA)

5-Aminolevulinic acid (5-ALA) is a delta amino acid naturally present in every living cell of the human body. 5-ALA is produced in the mitochondria as the first product of the porphyrin synthesis pathway and composes heme; exogenously supplemented 5-ALA helps in upregulating mitochondrial functions....

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Detalles Bibliográficos
Autores principales: Rehani, Peter R., Iftikhar, Hanaa, Nakajima, Motowo, Tanaka, Tohru, Jabbar, Zaid, Rehani, Riyadh N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874935/
https://www.ncbi.nlm.nih.gov/pubmed/31781665
http://dx.doi.org/10.1155/2019/4267357
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author Rehani, Peter R.
Iftikhar, Hanaa
Nakajima, Motowo
Tanaka, Tohru
Jabbar, Zaid
Rehani, Riyadh N.
author_facet Rehani, Peter R.
Iftikhar, Hanaa
Nakajima, Motowo
Tanaka, Tohru
Jabbar, Zaid
Rehani, Riyadh N.
author_sort Rehani, Peter R.
collection PubMed
description 5-Aminolevulinic acid (5-ALA) is a delta amino acid naturally present in every living cell of the human body. 5-ALA is produced in the mitochondria as the first product of the porphyrin synthesis pathway and composes heme; exogenously supplemented 5-ALA helps in upregulating mitochondrial functions. Mitochondrial dysfunction has been associated with the pathophysiology of diabetes mellitus. Thus, in this review, we evaluate the mechanisms of action and adverse effects of common medications used to treat type 2 diabetes mellitus as well as 5-ALA including its mechanism and possible use in diabetes management.
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spelling pubmed-68749352019-11-28 Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA) Rehani, Peter R. Iftikhar, Hanaa Nakajima, Motowo Tanaka, Tohru Jabbar, Zaid Rehani, Riyadh N. J Diabetes Res Review Article 5-Aminolevulinic acid (5-ALA) is a delta amino acid naturally present in every living cell of the human body. 5-ALA is produced in the mitochondria as the first product of the porphyrin synthesis pathway and composes heme; exogenously supplemented 5-ALA helps in upregulating mitochondrial functions. Mitochondrial dysfunction has been associated with the pathophysiology of diabetes mellitus. Thus, in this review, we evaluate the mechanisms of action and adverse effects of common medications used to treat type 2 diabetes mellitus as well as 5-ALA including its mechanism and possible use in diabetes management. Hindawi 2019-11-06 /pmc/articles/PMC6874935/ /pubmed/31781665 http://dx.doi.org/10.1155/2019/4267357 Text en Copyright © 2019 Peter R. Rehani et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rehani, Peter R.
Iftikhar, Hanaa
Nakajima, Motowo
Tanaka, Tohru
Jabbar, Zaid
Rehani, Riyadh N.
Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA)
title Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA)
title_full Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA)
title_fullStr Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA)
title_full_unstemmed Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA)
title_short Safety and Mode of Action of Diabetes Medications in comparison with 5-Aminolevulinic Acid (5-ALA)
title_sort safety and mode of action of diabetes medications in comparison with 5-aminolevulinic acid (5-ala)
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874935/
https://www.ncbi.nlm.nih.gov/pubmed/31781665
http://dx.doi.org/10.1155/2019/4267357
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