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Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea

Obstructive sleep apnea (OSA) can lead to serious complications such as coronary heart disease and hypertension due to oxidative stress. Sestrin2 expression is upregulated under conditions of oxidative stress. This study aimed to explore whether Sestrin2 was involved in OSA. OSA and healthy control...

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Detalles Bibliográficos
Autores principales: Jiang, Rong, Wang, Qiru, Zhai, Huifen, Du, Xiaohua, Sun, Shibo, Wang, Haoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874949/
https://www.ncbi.nlm.nih.gov/pubmed/31781313
http://dx.doi.org/10.1155/2019/2047674
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author Jiang, Rong
Wang, Qiru
Zhai, Huifen
Du, Xiaohua
Sun, Shibo
Wang, Haoyan
author_facet Jiang, Rong
Wang, Qiru
Zhai, Huifen
Du, Xiaohua
Sun, Shibo
Wang, Haoyan
author_sort Jiang, Rong
collection PubMed
description Obstructive sleep apnea (OSA) can lead to serious complications such as coronary heart disease and hypertension due to oxidative stress. Sestrin2 expression is upregulated under conditions of oxidative stress. This study aimed to explore whether Sestrin2 was involved in OSA. OSA and healthy control subjects were recruited and matched with age, gender, and body mass index (BMI). Plasma Sestrin2 levels were measured and compared. A multivariate stepwise regression model was used to detect the relationship between Sestrin2 and other variable factors. The Sestrin2 levels were compared between before and after four weeks treatment by nasal continuous positive airway pressure (nCPAP) in severe OSA patients. Fifty-seven subjects were divided into two groups: control group (39.33 ± 9.40 years, n = 21) and OSA group (38.81 ± 7.84 years, n = 36). Plasma Sestrin2 levels increased in the OSA group (control group 2.06 ± 1.76 ng/mL, OSA group 4.16 ± 2.37 ng/mL; P = 0.001). Sestrin2 levels decreased after four-week nCPAP treatment (pre-nCPAP 5.21 ± 2.32 ng/mL, post-nCPAP 4.01 ± 1.54 ng/mL; P = 0.004). Sestrin2 was positively correlated with apnea/hypopnea index (AHI) oxygen desaturation index, while negatively correlated with mean oxygen saturation. Moreover, these correlations remained unchanged after adjusting for gender, age, waist-to-hip ratio, and body mass index. Multiple regression analysis showed that there was an association between Sestrin2 and AHI. Our findings suggest that Sestrin2 is involved in OSA. The increase of plasma Sestrin2 is directly related to the severity of OSA. To some extent, Sestrin2 may be useful for determining the severity of OSA and monitoring the effect of CPAP. In addition, since some complications of OSA such as coronary heart disease and diabetes are usually related with oxidative stress, the role of Sestrin2 in those OSA complications needs further study.
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spelling pubmed-68749492019-11-28 Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea Jiang, Rong Wang, Qiru Zhai, Huifen Du, Xiaohua Sun, Shibo Wang, Haoyan Can Respir J Research Article Obstructive sleep apnea (OSA) can lead to serious complications such as coronary heart disease and hypertension due to oxidative stress. Sestrin2 expression is upregulated under conditions of oxidative stress. This study aimed to explore whether Sestrin2 was involved in OSA. OSA and healthy control subjects were recruited and matched with age, gender, and body mass index (BMI). Plasma Sestrin2 levels were measured and compared. A multivariate stepwise regression model was used to detect the relationship between Sestrin2 and other variable factors. The Sestrin2 levels were compared between before and after four weeks treatment by nasal continuous positive airway pressure (nCPAP) in severe OSA patients. Fifty-seven subjects were divided into two groups: control group (39.33 ± 9.40 years, n = 21) and OSA group (38.81 ± 7.84 years, n = 36). Plasma Sestrin2 levels increased in the OSA group (control group 2.06 ± 1.76 ng/mL, OSA group 4.16 ± 2.37 ng/mL; P = 0.001). Sestrin2 levels decreased after four-week nCPAP treatment (pre-nCPAP 5.21 ± 2.32 ng/mL, post-nCPAP 4.01 ± 1.54 ng/mL; P = 0.004). Sestrin2 was positively correlated with apnea/hypopnea index (AHI) oxygen desaturation index, while negatively correlated with mean oxygen saturation. Moreover, these correlations remained unchanged after adjusting for gender, age, waist-to-hip ratio, and body mass index. Multiple regression analysis showed that there was an association between Sestrin2 and AHI. Our findings suggest that Sestrin2 is involved in OSA. The increase of plasma Sestrin2 is directly related to the severity of OSA. To some extent, Sestrin2 may be useful for determining the severity of OSA and monitoring the effect of CPAP. In addition, since some complications of OSA such as coronary heart disease and diabetes are usually related with oxidative stress, the role of Sestrin2 in those OSA complications needs further study. Hindawi 2019-11-03 /pmc/articles/PMC6874949/ /pubmed/31781313 http://dx.doi.org/10.1155/2019/2047674 Text en Copyright © 2019 Rong Jiang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jiang, Rong
Wang, Qiru
Zhai, Huifen
Du, Xiaohua
Sun, Shibo
Wang, Haoyan
Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea
title Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea
title_full Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea
title_fullStr Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea
title_full_unstemmed Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea
title_short Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea
title_sort explorating the involvement of plasma sestrin2 in obstructive sleep apnea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874949/
https://www.ncbi.nlm.nih.gov/pubmed/31781313
http://dx.doi.org/10.1155/2019/2047674
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