Cargando…

Neuroprotection of Indole-Derivative Compound NC001-8 by the Regulation of the NRF2 Pathway in Parkinson's Disease Cell Models

Parkinson's disease (PD) is a common neurodegenerative disease accompanied by a loss of dopaminergic (DAergic) neurons. The development of therapies to prevent disease progression is the main goal of drug discovery. There is increasing evidence that oxidative stress and antioxidants may contrib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Pei-Cih, Lee-Chen, Guey-Jen, Chen, Chiung-Mei, Wu, Yih-Ru, Chen, Yi-Jing, Lin, Jia-Li, Lo, Yen-Shi, Yao, Ching-Fa, Chang, Kuo-Hsuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874971/ https://www.ncbi.nlm.nih.gov/pubmed/31781339 http://dx.doi.org/10.1155/2019/5074367

Ejemplares similares

Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson’s Disease
por: Chiu, Ya-Jen, et al.
Publicado: (2023)

Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity
por: Yang, Pei-Ning, et al.
Publicado: (2023)

Pathomechanism Characterization and Potential Therapeutics Identification for Parkinson’s Disease Targeting Neuroinflammation
por: Chen, Chiung-Mei, et al.
Publicado: (2021)

Lactulose and Melibiose Attenuate MPTP-Induced Parkinson’s Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy
por: Lin, Chih-Hsin, et al.
Publicado: (2020)

Isorhamnetin Attenuated the Release of Interleukin-6 from β-Amyloid-Activated Microglia and Mitigated Interleukin-6-Mediated Neurotoxicity
por: Wei, Pei-Cih, et al.
Publicado: (2022)

STK39, But Not BST1, HLA-DQB1, and SPPL2B Polymorphism, Is Associated With Han-Chinese Parkinson's Disease in Taiwan
por: Chang, Kuo-Hsuan, et al.
Publicado: (2015)

Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population
por: Chang, Kuo-Hsuan, et al.
Publicado: (2013)

Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation
por: Chen, I-Cheng, et al.
Publicado: (2018)

Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer’s disease cell and mouse models for neuroprotection and cognitive improvement
por: Chiu, Ya-Jen, et al.
Publicado: (2021)

Genetic Analysis of EGLN1 C127S Variant in Taiwanese Parkinson's Disease
por: Chiang, Han-Lin, et al.
Publicado: (2020)

Genetic Variants of LRRK2 in Taiwanese Parkinson’s Disease
por: Wu, Yih-Ru, et al.
Publicado: (2013)

New Synthetic 3-Benzoyl-5-Hydroxy-2H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPKα in SCA17 Cell Models
por: Chen, Chiung-Mei, et al.
Publicado: (2020)

Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation
por: Chiu, Ya-Jen, et al.
Publicado: (2020)

A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment
por: Chiu, Ya-Jen, et al.
Publicado: (2023)

Rare VPS35 A320V Variant in Taiwanese Parkinson’s Disease Indicates Disrupted CI-MPR Sorting and Impaired Mitochondrial Morphology
por: Wu, Yih-Ru, et al.
Publicado: (2020)

Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan
por: Chang, Kuo-Hsuan, et al.
Publicado: (2019)

Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models
por: Chen, Chiung-Mei, et al.
Publicado: (2019)

Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation
por: Chang, Kuo-Hsuan, et al.
Publicado: (2018)

Neuroprotection by Nrf2 in Parkinson’s disease model
Publicado: (2011)

Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein
por: Lin, Te-Hsien, et al.
Publicado: (2022)

Polymorphisms of ACMSD-TMEM163, MCCC1, and BCKDK-STX1B Are Not Associated with Parkinson's Disease in Taiwan
por: Chang, Kuo-Hsuan, et al.
Publicado: (2019)

FBXO7 Y52C Polymorphism as a Potential Protective Factor in Parkinson's Disease
por: Chen, Chiung-Mei, et al.
Publicado: (2014)

An NC-AFM and KPFM study of the adsorption of a triphenylene derivative on KBr(001)
por: Hinaut, Antoine, et al.
Publicado: (2012)

Alternations of Lipoprotein Profiles in the Plasma as Biomarkers of Huntington’s Disease
por: Chang, Kuo-Hsuan, et al.
Publicado: (2023)

Altered Aconitase 2 Activity in Huntington’s Disease Peripheral Blood Cells and Mouse Model Striatum
por: Chen, Chiung-Mei, et al.
Publicado: (2017)

Down-regulation of miR-9* in the peripheral leukocytes of Huntington’s disease patients
por: Chang, Kuo-Hsuan, et al.
Publicado: (2017)

The Role of Oxidative Stress in Parkinson’s Disease
por: Chang, Kuo-Hsuan, et al.
Publicado: (2020)

Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models
por: Kung, Pin-Jui, et al.
Publicado: (2014)

Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson’s Disease
por: Chang, Kuo-Hsuan, et al.
Publicado: (2023)

Aqueous Extract of Paeonia lactiflora and Paeoniflorin as Aggregation Reducers Targeting Chaperones in Cell Models of Spinocerebellar Ataxia 3
por: Chang, Kuo-Hsuan, et al.
Publicado: (2013)

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease
por: Chang, Kuo-Hsuan, et al.
Publicado: (2016)

Biomarker of Neuroinflammation in Parkinson’s Disease
por: Liu, Tsai-Wei, et al.
Publicado: (2022)

LRRK2 A419V Is Not Associated with Parkinson's Disease in Different Chinese Populations
por: Wu, Yih Ru, et al.
Publicado: (2012)

Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability
por: Chen, Chiung Mei, et al.
Publicado: (2020)

Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSC-Derived Neurons
por: Chen, I-Cheng, et al.
Publicado: (2019)

Associations of Matrix Metalloproteinase-9 and Tissue Inhibitory Factor-1 Polymorphisms With Parkinson Disease in Taiwan
por: Chen, Yi-Chun, et al.
Publicado: (2016)

Neuroprotective Capability of Narcissoside in 6-OHDA-Exposed Parkinson’s Disease Models through Enhancing the MiR200a/Nrf-2/GSH Axis and Mediating MAPK/Akt Associated Signaling Pathway
por: Fu, Ru-Huei, et al.
Publicado: (2022)

Spinocerebellar ataxia type 8 larger triplet expansion alters histone modification and induces RNA foci
por: Chen, I-Cheng, et al.
Publicado: (2009)

Association of TNF-α gene with spontaneous deep intracerebral hemorrhage in the Taiwan population: a case control study
por: Chen, Yi-Chun, et al.
Publicado: (2010)

Internal Ribosome Entry Segment Activity of ATXN8 Opposite Strand RNA
por: Chen, I-Cheng, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_fkpnnnrr9gdtia1h8tmrvtptkc