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Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress

Autophagy is a self-digestive process that degrades intracellular components, including damaged organelles, to maintain energy homeostasis and to cope with cellular stress. Autophagy plays a key role during development and adult tissue homeostasis, and growing evidence indicates that this catalytic...

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Autores principales: Roca-Agujetas, Vicente, de Dios, Cristina, Lestón, Laura, Marí, Montserrat, Morales, Albert, Colell, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875203/
https://www.ncbi.nlm.nih.gov/pubmed/31781334
http://dx.doi.org/10.1155/2019/3809308
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author Roca-Agujetas, Vicente
de Dios, Cristina
Lestón, Laura
Marí, Montserrat
Morales, Albert
Colell, Anna
author_facet Roca-Agujetas, Vicente
de Dios, Cristina
Lestón, Laura
Marí, Montserrat
Morales, Albert
Colell, Anna
author_sort Roca-Agujetas, Vicente
collection PubMed
description Autophagy is a self-digestive process that degrades intracellular components, including damaged organelles, to maintain energy homeostasis and to cope with cellular stress. Autophagy plays a key role during development and adult tissue homeostasis, and growing evidence indicates that this catalytic process also has a direct role in modulating aging. Although autophagy is essentially protective, depending on the cellular context and stimuli, autophagy outcome can lead to either abnormal cell growth or cell death. The autophagic process requires a tight regulation, with cellular events following distinct stages and governed by a wide molecular machinery. Reactive oxygen species (ROS) have been involved in autophagy regulation through multiple signaling pathways, and mitochondria, the main source of endogenous ROS, have emerged as essential signal transducers that mediate autophagy. In the present review, we aim to summarize the regulatory function of mitochondria in the autophagic process, particularly regarding the mitochondrial role as the coordination node in the autophagy signaling pathway, involving mitochondrial oxidative stress, and their participation as membrane donors in the initial steps of autophagosome assembly.
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spelling pubmed-68752032019-11-28 Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress Roca-Agujetas, Vicente de Dios, Cristina Lestón, Laura Marí, Montserrat Morales, Albert Colell, Anna Oxid Med Cell Longev Review Article Autophagy is a self-digestive process that degrades intracellular components, including damaged organelles, to maintain energy homeostasis and to cope with cellular stress. Autophagy plays a key role during development and adult tissue homeostasis, and growing evidence indicates that this catalytic process also has a direct role in modulating aging. Although autophagy is essentially protective, depending on the cellular context and stimuli, autophagy outcome can lead to either abnormal cell growth or cell death. The autophagic process requires a tight regulation, with cellular events following distinct stages and governed by a wide molecular machinery. Reactive oxygen species (ROS) have been involved in autophagy regulation through multiple signaling pathways, and mitochondria, the main source of endogenous ROS, have emerged as essential signal transducers that mediate autophagy. In the present review, we aim to summarize the regulatory function of mitochondria in the autophagic process, particularly regarding the mitochondrial role as the coordination node in the autophagy signaling pathway, involving mitochondrial oxidative stress, and their participation as membrane donors in the initial steps of autophagosome assembly. Hindawi 2019-11-04 /pmc/articles/PMC6875203/ /pubmed/31781334 http://dx.doi.org/10.1155/2019/3809308 Text en Copyright © 2019 Vicente Roca-Agujetas et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Roca-Agujetas, Vicente
de Dios, Cristina
Lestón, Laura
Marí, Montserrat
Morales, Albert
Colell, Anna
Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress
title Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress
title_full Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress
title_fullStr Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress
title_full_unstemmed Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress
title_short Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress
title_sort recent insights into the mitochondrial role in autophagy and its regulation by oxidative stress
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875203/
https://www.ncbi.nlm.nih.gov/pubmed/31781334
http://dx.doi.org/10.1155/2019/3809308
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