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Emerging Role of Ferroptosis in Acute Kidney Injury
Acute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875218/ https://www.ncbi.nlm.nih.gov/pubmed/31781351 http://dx.doi.org/10.1155/2019/8010614 |
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author | Hu, Zhaoxin Zhang, Hao Yang, Shi-kun Wu, Xueqin He, Dong Cao, Ke Zhang, Wei |
author_facet | Hu, Zhaoxin Zhang, Hao Yang, Shi-kun Wu, Xueqin He, Dong Cao, Ke Zhang, Wei |
author_sort | Hu, Zhaoxin |
collection | PubMed |
description | Acute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic cell death characterized by membrane lipid peroxide accumulation and polyunsaturated fatty acid consumption, and it plays essential roles in many diseases, including cancers and neurologic diseases. Recent studies have revealed an emerging role of ferroptosis in the pathophysiological processes of AKI. Here, in the present review, we summarized the most recent discoveries on the role of ferroptosis in the pathogenesis of AKI as well as its therapeutic potential in AKI. |
format | Online Article Text |
id | pubmed-6875218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-68752182019-11-28 Emerging Role of Ferroptosis in Acute Kidney Injury Hu, Zhaoxin Zhang, Hao Yang, Shi-kun Wu, Xueqin He, Dong Cao, Ke Zhang, Wei Oxid Med Cell Longev Review Article Acute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic cell death characterized by membrane lipid peroxide accumulation and polyunsaturated fatty acid consumption, and it plays essential roles in many diseases, including cancers and neurologic diseases. Recent studies have revealed an emerging role of ferroptosis in the pathophysiological processes of AKI. Here, in the present review, we summarized the most recent discoveries on the role of ferroptosis in the pathogenesis of AKI as well as its therapeutic potential in AKI. Hindawi 2019-10-31 /pmc/articles/PMC6875218/ /pubmed/31781351 http://dx.doi.org/10.1155/2019/8010614 Text en Copyright © 2019 Zhaoxin Hu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Hu, Zhaoxin Zhang, Hao Yang, Shi-kun Wu, Xueqin He, Dong Cao, Ke Zhang, Wei Emerging Role of Ferroptosis in Acute Kidney Injury |
title | Emerging Role of Ferroptosis in Acute Kidney Injury |
title_full | Emerging Role of Ferroptosis in Acute Kidney Injury |
title_fullStr | Emerging Role of Ferroptosis in Acute Kidney Injury |
title_full_unstemmed | Emerging Role of Ferroptosis in Acute Kidney Injury |
title_short | Emerging Role of Ferroptosis in Acute Kidney Injury |
title_sort | emerging role of ferroptosis in acute kidney injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875218/ https://www.ncbi.nlm.nih.gov/pubmed/31781351 http://dx.doi.org/10.1155/2019/8010614 |
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