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Oxidative Stress in Cell Death and Cardiovascular Diseases
ROS functions as a second messenger and modulates multiple signaling pathways under the physiological conditions. However, excessive intracellular ROS causes damage to the molecular components of the cell, which promotes the pathogenesis of various human diseases. Cardiovascular diseases are serious...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875219/ https://www.ncbi.nlm.nih.gov/pubmed/31781356 http://dx.doi.org/10.1155/2019/9030563 |
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author | Xu, Tao Ding, Wei Ji, Xiaoyu Ao, Xiang Liu, Ying Yu, Wanpeng Wang, Jianxun |
author_facet | Xu, Tao Ding, Wei Ji, Xiaoyu Ao, Xiang Liu, Ying Yu, Wanpeng Wang, Jianxun |
author_sort | Xu, Tao |
collection | PubMed |
description | ROS functions as a second messenger and modulates multiple signaling pathways under the physiological conditions. However, excessive intracellular ROS causes damage to the molecular components of the cell, which promotes the pathogenesis of various human diseases. Cardiovascular diseases are serious threats to human health with extremely high rates of morbidity and mortality. Dysregulation of cell death promotes the pathogenesis of cardiovascular diseases and is the clinical target during the disease treatment. Numerous studies show that ROS production is closely linked to the cell death process and promotes the occurrence and development of the cardiovascular diseases. In this review, we summarize the regulation of intracellular ROS, the roles of ROS played in the development of cardiovascular diseases, and the programmed cell death induced by intracellular ROS. We also focus on anti-ROS system and the potential application of anti-ROS strategy in the treatment of cardiovascular diseases. |
format | Online Article Text |
id | pubmed-6875219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-68752192019-11-28 Oxidative Stress in Cell Death and Cardiovascular Diseases Xu, Tao Ding, Wei Ji, Xiaoyu Ao, Xiang Liu, Ying Yu, Wanpeng Wang, Jianxun Oxid Med Cell Longev Review Article ROS functions as a second messenger and modulates multiple signaling pathways under the physiological conditions. However, excessive intracellular ROS causes damage to the molecular components of the cell, which promotes the pathogenesis of various human diseases. Cardiovascular diseases are serious threats to human health with extremely high rates of morbidity and mortality. Dysregulation of cell death promotes the pathogenesis of cardiovascular diseases and is the clinical target during the disease treatment. Numerous studies show that ROS production is closely linked to the cell death process and promotes the occurrence and development of the cardiovascular diseases. In this review, we summarize the regulation of intracellular ROS, the roles of ROS played in the development of cardiovascular diseases, and the programmed cell death induced by intracellular ROS. We also focus on anti-ROS system and the potential application of anti-ROS strategy in the treatment of cardiovascular diseases. Hindawi 2019-11-04 /pmc/articles/PMC6875219/ /pubmed/31781356 http://dx.doi.org/10.1155/2019/9030563 Text en Copyright © 2019 Tao Xu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Xu, Tao Ding, Wei Ji, Xiaoyu Ao, Xiang Liu, Ying Yu, Wanpeng Wang, Jianxun Oxidative Stress in Cell Death and Cardiovascular Diseases |
title | Oxidative Stress in Cell Death and Cardiovascular Diseases |
title_full | Oxidative Stress in Cell Death and Cardiovascular Diseases |
title_fullStr | Oxidative Stress in Cell Death and Cardiovascular Diseases |
title_full_unstemmed | Oxidative Stress in Cell Death and Cardiovascular Diseases |
title_short | Oxidative Stress in Cell Death and Cardiovascular Diseases |
title_sort | oxidative stress in cell death and cardiovascular diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875219/ https://www.ncbi.nlm.nih.gov/pubmed/31781356 http://dx.doi.org/10.1155/2019/9030563 |
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