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Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management
Osteoarthritis (OA) is a joint degenerative disease, which is prominent in the middle-aged and elderly population, often leading to repeated pain in the joints of patients and seriously affecting the life quality of patients. At present, the treatment of OA mainly depends on the surgery and drug tre...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875272/ https://www.ncbi.nlm.nih.gov/pubmed/31781642 http://dx.doi.org/10.1155/2019/7695768 |
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author | Ju, Cheng Liu, Renfeng Zhang, Yu Zhang, Feifei Sun, Jun Lv, Xiao-Bin Zhang, Zhiping |
author_facet | Ju, Cheng Liu, Renfeng Zhang, Yu Zhang, Feifei Sun, Jun Lv, Xiao-Bin Zhang, Zhiping |
author_sort | Ju, Cheng |
collection | PubMed |
description | Osteoarthritis (OA) is a joint degenerative disease, which is prominent in the middle-aged and elderly population, often leading to repeated pain in the joints of patients and seriously affecting the life quality of patients. At present, the treatment of OA mainly depends on the surgery and drug treatment. Nevertheless, these treatments still face many problems, such as surgical safety, complications, and drug side effects. Exosomes can be secreted and released by multiple cell types and have lipid bilayer membranes and contain abundant biological molecules, including proteins, lipids, and nucleic acids. Moreover, exosomes play a critical role in local and distal intercellular and intracellular communication. In recent years, several studies have found that exosomes can regulate the progression of OA and have a potential efficacy for OA treatment. Thus, in this article, we summarize and review the relevant research of exosomes in OA and emphasize the importance of exosomes in the development of OA. |
format | Online Article Text |
id | pubmed-6875272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-68752722019-11-28 Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management Ju, Cheng Liu, Renfeng Zhang, Yu Zhang, Feifei Sun, Jun Lv, Xiao-Bin Zhang, Zhiping Biomed Res Int Review Article Osteoarthritis (OA) is a joint degenerative disease, which is prominent in the middle-aged and elderly population, often leading to repeated pain in the joints of patients and seriously affecting the life quality of patients. At present, the treatment of OA mainly depends on the surgery and drug treatment. Nevertheless, these treatments still face many problems, such as surgical safety, complications, and drug side effects. Exosomes can be secreted and released by multiple cell types and have lipid bilayer membranes and contain abundant biological molecules, including proteins, lipids, and nucleic acids. Moreover, exosomes play a critical role in local and distal intercellular and intracellular communication. In recent years, several studies have found that exosomes can regulate the progression of OA and have a potential efficacy for OA treatment. Thus, in this article, we summarize and review the relevant research of exosomes in OA and emphasize the importance of exosomes in the development of OA. Hindawi 2019-11-03 /pmc/articles/PMC6875272/ /pubmed/31781642 http://dx.doi.org/10.1155/2019/7695768 Text en Copyright © 2019 Cheng Ju et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ju, Cheng Liu, Renfeng Zhang, Yu Zhang, Feifei Sun, Jun Lv, Xiao-Bin Zhang, Zhiping Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management |
title | Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management |
title_full | Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management |
title_fullStr | Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management |
title_full_unstemmed | Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management |
title_short | Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management |
title_sort | exosomes may be the potential new direction of research in osteoarthritis management |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875272/ https://www.ncbi.nlm.nih.gov/pubmed/31781642 http://dx.doi.org/10.1155/2019/7695768 |
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