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Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management

Osteoarthritis (OA) is a joint degenerative disease, which is prominent in the middle-aged and elderly population, often leading to repeated pain in the joints of patients and seriously affecting the life quality of patients. At present, the treatment of OA mainly depends on the surgery and drug tre...

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Autores principales: Ju, Cheng, Liu, Renfeng, Zhang, Yu, Zhang, Feifei, Sun, Jun, Lv, Xiao-Bin, Zhang, Zhiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875272/
https://www.ncbi.nlm.nih.gov/pubmed/31781642
http://dx.doi.org/10.1155/2019/7695768
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author Ju, Cheng
Liu, Renfeng
Zhang, Yu
Zhang, Feifei
Sun, Jun
Lv, Xiao-Bin
Zhang, Zhiping
author_facet Ju, Cheng
Liu, Renfeng
Zhang, Yu
Zhang, Feifei
Sun, Jun
Lv, Xiao-Bin
Zhang, Zhiping
author_sort Ju, Cheng
collection PubMed
description Osteoarthritis (OA) is a joint degenerative disease, which is prominent in the middle-aged and elderly population, often leading to repeated pain in the joints of patients and seriously affecting the life quality of patients. At present, the treatment of OA mainly depends on the surgery and drug treatment. Nevertheless, these treatments still face many problems, such as surgical safety, complications, and drug side effects. Exosomes can be secreted and released by multiple cell types and have lipid bilayer membranes and contain abundant biological molecules, including proteins, lipids, and nucleic acids. Moreover, exosomes play a critical role in local and distal intercellular and intracellular communication. In recent years, several studies have found that exosomes can regulate the progression of OA and have a potential efficacy for OA treatment. Thus, in this article, we summarize and review the relevant research of exosomes in OA and emphasize the importance of exosomes in the development of OA.
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spelling pubmed-68752722019-11-28 Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management Ju, Cheng Liu, Renfeng Zhang, Yu Zhang, Feifei Sun, Jun Lv, Xiao-Bin Zhang, Zhiping Biomed Res Int Review Article Osteoarthritis (OA) is a joint degenerative disease, which is prominent in the middle-aged and elderly population, often leading to repeated pain in the joints of patients and seriously affecting the life quality of patients. At present, the treatment of OA mainly depends on the surgery and drug treatment. Nevertheless, these treatments still face many problems, such as surgical safety, complications, and drug side effects. Exosomes can be secreted and released by multiple cell types and have lipid bilayer membranes and contain abundant biological molecules, including proteins, lipids, and nucleic acids. Moreover, exosomes play a critical role in local and distal intercellular and intracellular communication. In recent years, several studies have found that exosomes can regulate the progression of OA and have a potential efficacy for OA treatment. Thus, in this article, we summarize and review the relevant research of exosomes in OA and emphasize the importance of exosomes in the development of OA. Hindawi 2019-11-03 /pmc/articles/PMC6875272/ /pubmed/31781642 http://dx.doi.org/10.1155/2019/7695768 Text en Copyright © 2019 Cheng Ju et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ju, Cheng
Liu, Renfeng
Zhang, Yu
Zhang, Feifei
Sun, Jun
Lv, Xiao-Bin
Zhang, Zhiping
Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management
title Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management
title_full Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management
title_fullStr Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management
title_full_unstemmed Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management
title_short Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management
title_sort exosomes may be the potential new direction of research in osteoarthritis management
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875272/
https://www.ncbi.nlm.nih.gov/pubmed/31781642
http://dx.doi.org/10.1155/2019/7695768
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