A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature

Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, yet therapy is often hampered by immune-related adverse events (irAEs) which range from mild to severe life-threatening events. Musculoskeletal (MSK) irAEs leading to discontinuation of ICIs are uncommon but increasingl...

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Detalles Bibliográficos
Autores principales: Thapa, Bicky, Ali, Asad, Nair, Raunak, Vashisht, Rishik, Calabrese, Cassandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875374/
https://www.ncbi.nlm.nih.gov/pubmed/31781462
http://dx.doi.org/10.1155/2019/1326734
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author Thapa, Bicky
Ali, Asad
Nair, Raunak
Vashisht, Rishik
Calabrese, Cassandra
author_facet Thapa, Bicky
Ali, Asad
Nair, Raunak
Vashisht, Rishik
Calabrese, Cassandra
author_sort Thapa, Bicky
collection PubMed
description Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, yet therapy is often hampered by immune-related adverse events (irAEs) which range from mild to severe life-threatening events. Musculoskeletal (MSK) irAEs leading to discontinuation of ICIs are uncommon but increasingly recognized. We report a challenging case of severe immune-related seronegative inflammatory arthritis due to nivolumab in a patient with stage IV metastatic adenocarcinoma.
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spelling pubmed-68753742019-11-28 A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature Thapa, Bicky Ali, Asad Nair, Raunak Vashisht, Rishik Calabrese, Cassandra Case Rep Rheumatol Case Report Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer, yet therapy is often hampered by immune-related adverse events (irAEs) which range from mild to severe life-threatening events. Musculoskeletal (MSK) irAEs leading to discontinuation of ICIs are uncommon but increasingly recognized. We report a challenging case of severe immune-related seronegative inflammatory arthritis due to nivolumab in a patient with stage IV metastatic adenocarcinoma. Hindawi 2019-11-03 /pmc/articles/PMC6875374/ /pubmed/31781462 http://dx.doi.org/10.1155/2019/1326734 Text en Copyright © 2019 Bicky Thapa et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Thapa, Bicky
Ali, Asad
Nair, Raunak
Vashisht, Rishik
Calabrese, Cassandra
A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature
title A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature
title_full A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature
title_fullStr A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature
title_full_unstemmed A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature
title_short A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature
title_sort case of severe seronegative inflammatory arthritis due to nivolumab and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875374/
https://www.ncbi.nlm.nih.gov/pubmed/31781462
http://dx.doi.org/10.1155/2019/1326734
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