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Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction

A complicated form of spastic paraplegia is a neurodegenerative disorder presenting as progressive spasticity in the bilateral lower limbs accompanied by some clinical features. The present case showed spastic paralysis and hyperreflexia in all extremities as well as lead pipe rigidity in the neck a...

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Autores principales: Sasaki, Ryo, Ohta, Yasuyuki, Sato, Kota, Tadokoro, Koh, Takahashi, Yoshiaki, Shang, Jingwei, Takemoto, Mami, Hishikawa, Nozomi, Yamashita, Toru, Ishiura, Hiroyuki, Tsuji, Shoji, Abe, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875453/
https://www.ncbi.nlm.nih.gov/pubmed/31292381
http://dx.doi.org/10.2169/internalmedicine.2765-19
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author Sasaki, Ryo
Ohta, Yasuyuki
Sato, Kota
Tadokoro, Koh
Takahashi, Yoshiaki
Shang, Jingwei
Takemoto, Mami
Hishikawa, Nozomi
Yamashita, Toru
Ishiura, Hiroyuki
Tsuji, Shoji
Abe, Koji
author_facet Sasaki, Ryo
Ohta, Yasuyuki
Sato, Kota
Tadokoro, Koh
Takahashi, Yoshiaki
Shang, Jingwei
Takemoto, Mami
Hishikawa, Nozomi
Yamashita, Toru
Ishiura, Hiroyuki
Tsuji, Shoji
Abe, Koji
author_sort Sasaki, Ryo
collection PubMed
description A complicated form of spastic paraplegia is a neurodegenerative disorder presenting as progressive spasticity in the bilateral lower limbs accompanied by some clinical features. The present case showed spastic paralysis and hyperreflexia in all extremities as well as lead pipe rigidity in the neck and bilateral upper extremities (R < L), decreased scores on frontal cognitive tests, a decreased accumulation of the right dorsal putamen on a DAT scan, and hypoperfusion of the bilateral frontal lobes on (99m)Tc-ECD single photon emission computed tomography (SPECT). The present case provides a new spectrum of spastic paraplegia based on the evidence of clinical scores and the findings of brain functional imaging.
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spelling pubmed-68754532019-11-25 Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction Sasaki, Ryo Ohta, Yasuyuki Sato, Kota Tadokoro, Koh Takahashi, Yoshiaki Shang, Jingwei Takemoto, Mami Hishikawa, Nozomi Yamashita, Toru Ishiura, Hiroyuki Tsuji, Shoji Abe, Koji Intern Med Case Report A complicated form of spastic paraplegia is a neurodegenerative disorder presenting as progressive spasticity in the bilateral lower limbs accompanied by some clinical features. The present case showed spastic paralysis and hyperreflexia in all extremities as well as lead pipe rigidity in the neck and bilateral upper extremities (R < L), decreased scores on frontal cognitive tests, a decreased accumulation of the right dorsal putamen on a DAT scan, and hypoperfusion of the bilateral frontal lobes on (99m)Tc-ECD single photon emission computed tomography (SPECT). The present case provides a new spectrum of spastic paraplegia based on the evidence of clinical scores and the findings of brain functional imaging. The Japanese Society of Internal Medicine 2019-07-10 2019-11-01 /pmc/articles/PMC6875453/ /pubmed/31292381 http://dx.doi.org/10.2169/internalmedicine.2765-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sasaki, Ryo
Ohta, Yasuyuki
Sato, Kota
Tadokoro, Koh
Takahashi, Yoshiaki
Shang, Jingwei
Takemoto, Mami
Hishikawa, Nozomi
Yamashita, Toru
Ishiura, Hiroyuki
Tsuji, Shoji
Abe, Koji
Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction
title Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction
title_full Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction
title_fullStr Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction
title_full_unstemmed Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction
title_short Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction
title_sort spastic paraplegia accompanied by extrapyramidal sign and frontal cognitive dysfunction
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875453/
https://www.ncbi.nlm.nih.gov/pubmed/31292381
http://dx.doi.org/10.2169/internalmedicine.2765-19
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