Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine “Goreisan”

Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, ex...

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Detalles Bibliográficos
Autores principales: Sasaki, Hisashi, Kimizuka, Yoshifumi, Ogata, Hiraku, Okada, Yosuke, Ota, Shinichiro, Sano, Tomoya, Watanabe, Chie, Maki, Yohei, Yamamoto, Takayuki, Tagami, Yoichi, Miyata, Jun, Hayashi, Nobuyoshi, Fujikura, Yuji, Kawana, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875454/
https://www.ncbi.nlm.nih.gov/pubmed/31292394
http://dx.doi.org/10.2169/internalmedicine.3002-19
Descripción
Sumario:Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, except for steroids. To the best of our knowledge, this is the first case of dasatinib-related chylothorax which was successfully controlled by combining diuretics with the Japanese herbal medicine “Goreisan.” “Goreisan” is known to inhibit aquaporin channels and regulate the water flow. Our findings showed that “Goreisan” is an effective treatment option for uncontrollable dasatinib-related chylothorax.

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