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Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine “Goreisan”
Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, ex...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Japanese Society of Internal Medicine
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875454/ https://www.ncbi.nlm.nih.gov/pubmed/31292394 http://dx.doi.org/10.2169/internalmedicine.3002-19 |
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| author | Sasaki, Hisashi Kimizuka, Yoshifumi Ogata, Hiraku Okada, Yosuke Ota, Shinichiro Sano, Tomoya Watanabe, Chie Maki, Yohei Yamamoto, Takayuki Tagami, Yoichi Miyata, Jun Hayashi, Nobuyoshi Fujikura, Yuji Kawana, Akihiko |
| author_facet | Sasaki, Hisashi Kimizuka, Yoshifumi Ogata, Hiraku Okada, Yosuke Ota, Shinichiro Sano, Tomoya Watanabe, Chie Maki, Yohei Yamamoto, Takayuki Tagami, Yoichi Miyata, Jun Hayashi, Nobuyoshi Fujikura, Yuji Kawana, Akihiko |
| author_sort | Sasaki, Hisashi |
| collection | PubMed |
| description | Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, except for steroids. To the best of our knowledge, this is the first case of dasatinib-related chylothorax which was successfully controlled by combining diuretics with the Japanese herbal medicine “Goreisan.” “Goreisan” is known to inhibit aquaporin channels and regulate the water flow. Our findings showed that “Goreisan” is an effective treatment option for uncontrollable dasatinib-related chylothorax. |
| format | Online Article Text |
| id | pubmed-6875454 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | The Japanese Society of Internal Medicine |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68754542019-11-25 Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine “Goreisan” Sasaki, Hisashi Kimizuka, Yoshifumi Ogata, Hiraku Okada, Yosuke Ota, Shinichiro Sano, Tomoya Watanabe, Chie Maki, Yohei Yamamoto, Takayuki Tagami, Yoichi Miyata, Jun Hayashi, Nobuyoshi Fujikura, Yuji Kawana, Akihiko Intern Med Case Report Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, except for steroids. To the best of our knowledge, this is the first case of dasatinib-related chylothorax which was successfully controlled by combining diuretics with the Japanese herbal medicine “Goreisan.” “Goreisan” is known to inhibit aquaporin channels and regulate the water flow. Our findings showed that “Goreisan” is an effective treatment option for uncontrollable dasatinib-related chylothorax. The Japanese Society of Internal Medicine 2019-07-10 2019-11-01 /pmc/articles/PMC6875454/ /pubmed/31292394 http://dx.doi.org/10.2169/internalmedicine.3002-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Case Report Sasaki, Hisashi Kimizuka, Yoshifumi Ogata, Hiraku Okada, Yosuke Ota, Shinichiro Sano, Tomoya Watanabe, Chie Maki, Yohei Yamamoto, Takayuki Tagami, Yoichi Miyata, Jun Hayashi, Nobuyoshi Fujikura, Yuji Kawana, Akihiko Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine “Goreisan” |
| title | Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine “Goreisan” |
| title_full | Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine “Goreisan” |
| title_fullStr | Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine “Goreisan” |
| title_full_unstemmed | Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine “Goreisan” |
| title_short | Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine “Goreisan” |
| title_sort | successful control of dasatinib-related chylothorax by the japanese herbal medicine “goreisan” |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875454/ https://www.ncbi.nlm.nih.gov/pubmed/31292394 http://dx.doi.org/10.2169/internalmedicine.3002-19 |
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