Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities

Quantitative systems pharmacology (QSP) approaches have been increasingly applied in the pharmaceutical since the landmark white paper published in 2011 by a National Institutes of Health working group brought attention to the discipline. In this perspective, we discuss QSP in the context of other m...

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Autores principales: Bradshaw, Erica L., Spilker, Mary E., Zang, Richard, Bansal, Loveleena, He, Handan, Jones, Rhys D.O., Le, Kha, Penney, Mark, Schuck, Edgar, Topp, Brian, Tsai, Alice, Xu, Christine, Nijsen, Marjoleen J.M.A., Chan, Jason R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
White Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875708/
https://www.ncbi.nlm.nih.gov/pubmed/31535440
http://dx.doi.org/10.1002/psp4.12463
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author Bradshaw, Erica L.
Spilker, Mary E.
Zang, Richard
Bansal, Loveleena
He, Handan
Jones, Rhys D.O.
Le, Kha
Penney, Mark
Schuck, Edgar
Topp, Brian
Tsai, Alice
Xu, Christine
Nijsen, Marjoleen J.M.A.
Chan, Jason R.
author_facet Bradshaw, Erica L.
Spilker, Mary E.
Zang, Richard
Bansal, Loveleena
He, Handan
Jones, Rhys D.O.
Le, Kha
Penney, Mark
Schuck, Edgar
Topp, Brian
Tsai, Alice
Xu, Christine
Nijsen, Marjoleen J.M.A.
Chan, Jason R.
author_sort Bradshaw, Erica L.
collection PubMed
description Quantitative systems pharmacology (QSP) approaches have been increasingly applied in the pharmaceutical since the landmark white paper published in 2011 by a National Institutes of Health working group brought attention to the discipline. In this perspective, we discuss QSP in the context of other modeling approaches and highlight the impact of QSP across various stages of drug development and therapeutic areas. We discuss challenges to the field as well as future opportunities.
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spelling pubmed-68757082019-11-29 Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities Bradshaw, Erica L. Spilker, Mary E. Zang, Richard Bansal, Loveleena He, Handan Jones, Rhys D.O. Le, Kha Penney, Mark Schuck, Edgar Topp, Brian Tsai, Alice Xu, Christine Nijsen, Marjoleen J.M.A. Chan, Jason R. CPT Pharmacometrics Syst Pharmacol White Paper Quantitative systems pharmacology (QSP) approaches have been increasingly applied in the pharmaceutical since the landmark white paper published in 2011 by a National Institutes of Health working group brought attention to the discipline. In this perspective, we discuss QSP in the context of other modeling approaches and highlight the impact of QSP across various stages of drug development and therapeutic areas. We discuss challenges to the field as well as future opportunities. John Wiley and Sons Inc. 2019-10-25 2019-11 /pmc/articles/PMC6875708/ /pubmed/31535440 http://dx.doi.org/10.1002/psp4.12463 Text en © 2019 Takeda California, Inc CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle White Paper
Bradshaw, Erica L.
Spilker, Mary E.
Zang, Richard
Bansal, Loveleena
He, Handan
Jones, Rhys D.O.
Le, Kha
Penney, Mark
Schuck, Edgar
Topp, Brian
Tsai, Alice
Xu, Christine
Nijsen, Marjoleen J.M.A.
Chan, Jason R.
Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities
title Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities
title_full Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities
title_fullStr Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities
title_full_unstemmed Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities
title_short Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities
title_sort applications of quantitative systems pharmacology in model‐informed drug discovery: perspective on impact and opportunities
topic White Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875708/
https://www.ncbi.nlm.nih.gov/pubmed/31535440
http://dx.doi.org/10.1002/psp4.12463
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