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Visualizing Neural Pathways Affected by Alcohol in Animals

Alcohol has many short- and long-term effects on functional units of nerve cells, or neural pathways, in the brain. Imaging studies in laboratory animals, particularly studies using autoradiographic detection methods, allow researchers to analyze the activities of these pathways as well as alcohol’s...

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Autores principales: Lyons, David, Porrino, Linda J., Hiller-Sturmhöfel, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute on Alcohol Abuse and Alcoholism 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875736/
https://www.ncbi.nlm.nih.gov/pubmed/31798080
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author Lyons, David
Porrino, Linda J.
Hiller-Sturmhöfel, Susanne
author_facet Lyons, David
Porrino, Linda J.
Hiller-Sturmhöfel, Susanne
author_sort Lyons, David
collection PubMed
description Alcohol has many short- and long-term effects on functional units of nerve cells, or neural pathways, in the brain. Imaging studies in laboratory animals, particularly studies using autoradiographic detection methods, allow researchers to analyze the activities of these pathways as well as alcohol’s effects on them. Commonly used techniques measure blood flow, glucose utilization, protein synthesis, and the activity of the enzyme cytochrome oxidase throughout the animal’s brain. Using these approaches, researchers have investigated alcohol’s effects both in animals that receive alcohol for the first time and in animals with a history of alcohol exposure. These studies demonstrate that different alcohol doses affect different neural pathways and that the affected brain areas also vary depending on the time that has elapsed since alcohol ingestion. Moreover, chronic alcohol use can markedly alter the baseline activity of certain neural pathways, even in animals that are not alcohol dependent.
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spelling pubmed-68757362019-12-03 Visualizing Neural Pathways Affected by Alcohol in Animals Lyons, David Porrino, Linda J. Hiller-Sturmhöfel, Susanne Alcohol Health Res World Articles Alcohol has many short- and long-term effects on functional units of nerve cells, or neural pathways, in the brain. Imaging studies in laboratory animals, particularly studies using autoradiographic detection methods, allow researchers to analyze the activities of these pathways as well as alcohol’s effects on them. Commonly used techniques measure blood flow, glucose utilization, protein synthesis, and the activity of the enzyme cytochrome oxidase throughout the animal’s brain. Using these approaches, researchers have investigated alcohol’s effects both in animals that receive alcohol for the first time and in animals with a history of alcohol exposure. These studies demonstrate that different alcohol doses affect different neural pathways and that the affected brain areas also vary depending on the time that has elapsed since alcohol ingestion. Moreover, chronic alcohol use can markedly alter the baseline activity of certain neural pathways, even in animals that are not alcohol dependent. National Institute on Alcohol Abuse and Alcoholism 1995 /pmc/articles/PMC6875736/ /pubmed/31798080 Text en http://creativecommons.org/publicdomain/mark/1.0/ Unless otherwise noted in the text, all material appearing in this journal is in the public domain and may be reproduced without permission. Citation of the source is appreciated.
spellingShingle Articles
Lyons, David
Porrino, Linda J.
Hiller-Sturmhöfel, Susanne
Visualizing Neural Pathways Affected by Alcohol in Animals
title Visualizing Neural Pathways Affected by Alcohol in Animals
title_full Visualizing Neural Pathways Affected by Alcohol in Animals
title_fullStr Visualizing Neural Pathways Affected by Alcohol in Animals
title_full_unstemmed Visualizing Neural Pathways Affected by Alcohol in Animals
title_short Visualizing Neural Pathways Affected by Alcohol in Animals
title_sort visualizing neural pathways affected by alcohol in animals
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875736/
https://www.ncbi.nlm.nih.gov/pubmed/31798080
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