Cargando…

Molecular Biology

Recent advances in molecular biology techniques permit scientists to identify genetic contributions to alcoholism. Two main types of technology are commonly used to identify genes that cause or predispose a person to a disease: positional cloning techniques and candidate gene techniques. Positional...

Descripción completa

Detalles Bibliográficos
Autor principal: Goate, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute on Alcohol Abuse and Alcoholism 1995
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875771/
https://www.ncbi.nlm.nih.gov/pubmed/31798077
_version_ 1783473090255126528
author Goate, Alison M.
author_facet Goate, Alison M.
author_sort Goate, Alison M.
collection PubMed
description Recent advances in molecular biology techniques permit scientists to identify genetic contributions to alcoholism. Two main types of technology are commonly used to identify genes that cause or predispose a person to a disease: positional cloning techniques and candidate gene techniques. Positional cloning techniques allow disease genes to be identified based solely on their location within the genome without prior knowledge of the gene’s function. Techniques for confirming the role of candidate genes rely on sufficient prior understanding of the disease process to implicate possible disease-related genes. Scientists use cloning techniques or the application of certain enzymes to reproduce a candidate gene in sufficient quantity for study. As the human genome project progresses and the gene map becomes increasingly complete, more and more disease genes will be identified through a combination of positional cloning and the candidate gene approach.
format Online
Article
Text
id pubmed-6875771
institution National Center for Biotechnology Information
language English
publishDate 1995
publisher National Institute on Alcohol Abuse and Alcoholism
record_format MEDLINE/PubMed
spelling pubmed-68757712019-12-03 Molecular Biology Goate, Alison M. Alcohol Health Res World Tools of Genetic Research Recent advances in molecular biology techniques permit scientists to identify genetic contributions to alcoholism. Two main types of technology are commonly used to identify genes that cause or predispose a person to a disease: positional cloning techniques and candidate gene techniques. Positional cloning techniques allow disease genes to be identified based solely on their location within the genome without prior knowledge of the gene’s function. Techniques for confirming the role of candidate genes rely on sufficient prior understanding of the disease process to implicate possible disease-related genes. Scientists use cloning techniques or the application of certain enzymes to reproduce a candidate gene in sufficient quantity for study. As the human genome project progresses and the gene map becomes increasingly complete, more and more disease genes will be identified through a combination of positional cloning and the candidate gene approach. National Institute on Alcohol Abuse and Alcoholism 1995 /pmc/articles/PMC6875771/ /pubmed/31798077 Text en http://creativecommons.org/publicdomain/mark/1.0/ Unless otherwise noted in the text, all material appearing in this journal is in the public domain and may be reproduced without permission. Citation of the source is appreciated.
spellingShingle Tools of Genetic Research
Goate, Alison M.
Molecular Biology
title Molecular Biology
title_full Molecular Biology
title_fullStr Molecular Biology
title_full_unstemmed Molecular Biology
title_short Molecular Biology
title_sort molecular biology
topic Tools of Genetic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875771/
https://www.ncbi.nlm.nih.gov/pubmed/31798077
work_keys_str_mv AT goatealisonm molecularbiology