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Is There any Mean to Postpone The Menopausal Ovarian Senescence?
The ovarian reserve (OR) gradually decreases throughout the female fertile life. This continuous depletion in OR is irreversible. This occurs through a programmed cell death, known as apoptosis. Some factors hasten such depletion, such as chemo- and radio-therapy. Others have been investigated in tr...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Royan Institute
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875855/ https://www.ncbi.nlm.nih.gov/pubmed/31710197 http://dx.doi.org/10.22074/ijfs.2020.5797 |
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author | Abdelmonem, Awad Hegazy |
author_facet | Abdelmonem, Awad Hegazy |
author_sort | Abdelmonem, Awad Hegazy |
collection | PubMed |
description | The ovarian reserve (OR) gradually decreases throughout the female fertile life. This continuous depletion in OR is irreversible. This occurs through a programmed cell death, known as apoptosis. Some factors hasten such depletion, such as chemo- and radio-therapy. Others have been investigated in trials to preserve the OR including gonadotropins, cytokines, growth hormones, nitric oxide and reorganization of the actin cytoskeleton. Loss of OR occurs normally at the menopausal age, a stage called menopausal ovarian senescence. At some periods, there are other sources for ovarian hormones that are away from the ovary, like during use of contraceptive pills and at pregnancy after formation of placenta. Future trials to preserve ovarian follicles at these periods might postpone the onset of menopause and hence lengthen the fertile female age. |
format | Online Article Text |
id | pubmed-6875855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-68758552020-01-01 Is There any Mean to Postpone The Menopausal Ovarian Senescence? Abdelmonem, Awad Hegazy Int J Fertil Steril Original Article The ovarian reserve (OR) gradually decreases throughout the female fertile life. This continuous depletion in OR is irreversible. This occurs through a programmed cell death, known as apoptosis. Some factors hasten such depletion, such as chemo- and radio-therapy. Others have been investigated in trials to preserve the OR including gonadotropins, cytokines, growth hormones, nitric oxide and reorganization of the actin cytoskeleton. Loss of OR occurs normally at the menopausal age, a stage called menopausal ovarian senescence. At some periods, there are other sources for ovarian hormones that are away from the ovary, like during use of contraceptive pills and at pregnancy after formation of placenta. Future trials to preserve ovarian follicles at these periods might postpone the onset of menopause and hence lengthen the fertile female age. Royan Institute 2020 2019-11-11 /pmc/articles/PMC6875855/ /pubmed/31710197 http://dx.doi.org/10.22074/ijfs.2020.5797 Text en The Cell Journal (Yakhteh) is an open access journal which means the articles are freely available online for any individual author to download and use the providing address. The journal is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported License which allows the author(s) to hold the copyright without restrictions that is permitting unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited. http://creativecommons.org/licenses/by/3/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Abdelmonem, Awad Hegazy Is There any Mean to Postpone The Menopausal Ovarian Senescence? |
title | Is There any Mean to Postpone The Menopausal Ovarian Senescence? |
title_full | Is There any Mean to Postpone The Menopausal Ovarian Senescence? |
title_fullStr | Is There any Mean to Postpone The Menopausal Ovarian Senescence? |
title_full_unstemmed | Is There any Mean to Postpone The Menopausal Ovarian Senescence? |
title_short | Is There any Mean to Postpone The Menopausal Ovarian Senescence? |
title_sort | is there any mean to postpone the menopausal ovarian senescence? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875855/ https://www.ncbi.nlm.nih.gov/pubmed/31710197 http://dx.doi.org/10.22074/ijfs.2020.5797 |
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