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Genome-Scale Characterization of Toxicity-Induced Metabolic Alterations in Primary Hepatocytes

Context-specific GEnome-scale metabolic Network REconstructions (GENREs) provide a means to understand cellular metabolism at a deeper level of physiological detail. Here, we use transcriptomics data from chemically-exposed rat hepatocytes to constrain a GENRE of rat hepatocyte metabolism and predic...

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Detalles Bibliográficos
Autores principales:	Rawls, Kristopher D, Blais, Edik M, Dougherty, Bonnie V, Vinnakota, Kalyan C, Pannala, Venkat R, Wallqvist, Anders, Kolling, Glynis L, Papin, Jason A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Computational Toxicology and Databases
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876259/ https://www.ncbi.nlm.nih.gov/pubmed/31501904 http://dx.doi.org/10.1093/toxsci/kfz197

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