Altered expression of lncRNA NCK1-AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia

Long non-coding (lnc)RNA NCK1 antisense RNA 1 (NCK1-AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown. It was revealed in the present study that plasma NCK1-AS1 was upregulated in patients with PC when compared with patients with be...

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Autores principales: Guan, Zhihui, Song, Yuwei, Ma, Jinguo, Li, Feng, Zhao, Xiaojun, Liang, Guodong, An, Haiquan, Pu, Jinxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876338/
https://www.ncbi.nlm.nih.gov/pubmed/31807161
http://dx.doi.org/10.3892/ol.2019.11039
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author Guan, Zhihui
Song, Yuwei
Ma, Jinguo
Li, Feng
Zhao, Xiaojun
Liang, Guodong
An, Haiquan
Pu, Jinxian
author_facet Guan, Zhihui
Song, Yuwei
Ma, Jinguo
Li, Feng
Zhao, Xiaojun
Liang, Guodong
An, Haiquan
Pu, Jinxian
author_sort Guan, Zhihui
collection PubMed
description Long non-coding (lnc)RNA NCK1 antisense RNA 1 (NCK1-AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown. It was revealed in the present study that plasma NCK1-AS1 was upregulated in patients with PC when compared with patients with benign prostatic hyperplasia (BPH) and healthy controls. Upregulation of NCK1-AS1 distinguished patients with PC from patients with BPH and healthy controls. Overexpression of NCK1-AS1 led to significantly upregulated transforming growth factor (TGF)-β1, while TGF-β1 overexpression failed to significantly affect NCK1-AS1 in PC cells. NCK1-AS1 overexpression led to promoted migration and invasion. TGF-β inhibitor played an opposite role and attenuated the effects of NCK1-AS1 overexpression. Therefore, NCK1-AS1 may upregulate TGF-β1 to promote PC.
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spelling pubmed-68763382019-12-05 Altered expression of lncRNA NCK1-AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia Guan, Zhihui Song, Yuwei Ma, Jinguo Li, Feng Zhao, Xiaojun Liang, Guodong An, Haiquan Pu, Jinxian Oncol Lett Articles Long non-coding (lnc)RNA NCK1 antisense RNA 1 (NCK1-AS1) has been characterized as an oncogene in cervical cancer, while its role in prostate cancer (PC) remains unknown. It was revealed in the present study that plasma NCK1-AS1 was upregulated in patients with PC when compared with patients with benign prostatic hyperplasia (BPH) and healthy controls. Upregulation of NCK1-AS1 distinguished patients with PC from patients with BPH and healthy controls. Overexpression of NCK1-AS1 led to significantly upregulated transforming growth factor (TGF)-β1, while TGF-β1 overexpression failed to significantly affect NCK1-AS1 in PC cells. NCK1-AS1 overexpression led to promoted migration and invasion. TGF-β inhibitor played an opposite role and attenuated the effects of NCK1-AS1 overexpression. Therefore, NCK1-AS1 may upregulate TGF-β1 to promote PC. D.A. Spandidos 2019-12 2019-11-01 /pmc/articles/PMC6876338/ /pubmed/31807161 http://dx.doi.org/10.3892/ol.2019.11039 Text en Copyright: © Guan et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Guan, Zhihui
Song, Yuwei
Ma, Jinguo
Li, Feng
Zhao, Xiaojun
Liang, Guodong
An, Haiquan
Pu, Jinxian
Altered expression of lncRNA NCK1-AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia
title Altered expression of lncRNA NCK1-AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia
title_full Altered expression of lncRNA NCK1-AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia
title_fullStr Altered expression of lncRNA NCK1-AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia
title_full_unstemmed Altered expression of lncRNA NCK1-AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia
title_short Altered expression of lncRNA NCK1-AS1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia
title_sort altered expression of lncrna nck1-as1 distinguished patients with prostate cancer from those with benign prostatic hyperplasia
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876338/
https://www.ncbi.nlm.nih.gov/pubmed/31807161
http://dx.doi.org/10.3892/ol.2019.11039
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