Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance

Most cancers are resistant to anti-PD-1/PD-L1 and chemotherapy. Herein we identify PDLIM2 as a tumor suppressor particularly important for lung cancer therapeutic responses. While PDLIM2 is epigenetically repressed in human lung cancer, associating with therapeutic resistance and poor prognosis, its...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Fan, Li, Liwen, Yan, Pengrong, Zhou, Jingjiao, Shapiro, Steven D., Xiao, Gutian, Qu, Zhaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876573/
https://www.ncbi.nlm.nih.gov/pubmed/31757943
http://dx.doi.org/10.1038/s41467-019-13331-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876573/
https://www.ncbi.nlm.nih.gov/pubmed/31757943
http://dx.doi.org/10.1038/s41467-019-13331-x

Ejemplares similares