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Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance

Most cancers are resistant to anti-PD-1/PD-L1 and chemotherapy. Herein we identify PDLIM2 as a tumor suppressor particularly important for lung cancer therapeutic responses. While PDLIM2 is epigenetically repressed in human lung cancer, associating with therapeutic resistance and poor prognosis, its...

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Detalles Bibliográficos
Autores principales:	Sun, Fan, Li, Liwen, Yan, Pengrong, Zhou, Jingjiao, Shapiro, Steven D., Xiao, Gutian, Qu, Zhaoxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876573/ https://www.ncbi.nlm.nih.gov/pubmed/31757943 http://dx.doi.org/10.1038/s41467-019-13331-x

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