Resolving the fibrotic niche of human liver cirrhosis at single cell level

Currently there are no effective antifibrotic therapies for liver cirrhosis, a major killer worldwide. To obtain a cellular resolution of directly-relevant pathogenesis and to inform therapeutic design, we profile the transcriptomes of over 100,000 human single cells, yielding molecular definitions...

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Detalles Bibliográficos
Autores principales: Ramachandran, P, Dobie, R, Wilson-Kanamori, JR, Dora, EF, Henderson, BEP, Luu, NT, Portman, JR, Matchett, KP, Brice, M, Marwick, JA, Taylor, RS, Efremova, M, Vento-Tormo, R, Carragher, NO, Kendall, TJ, Fallowfield, JA, Harrison, EM, Mole, DJ, Wigmore, SJ, Newsome, PN, Weston, CJ, Iredale, JP, Tacke, F, Pollard, JW, Ponting, CP, Marioni, JC, Teichmann, SA, Henderson, NC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876711/
https://www.ncbi.nlm.nih.gov/pubmed/31597160
http://dx.doi.org/10.1038/s41586-019-1631-3

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