The S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε

Replication fork stalling and accumulation of single-stranded DNA trigger the S phase checkpoint, a signalling cascade that, in budding yeast, leads to the activation of the Rad53 kinase. Rad53 is essential in maintaining cell viability, but its targets of regulation are still partially unknown. Her...

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Detalles Bibliográficos
Autores principales: Winczura, Alicja, Appanah, Rowin, Tatham, Michael H., Hay, Ronald T., De Piccoli, Giacomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876773/
https://www.ncbi.nlm.nih.gov/pubmed/31765407
http://dx.doi.org/10.1371/journal.pgen.1008427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876773/
https://www.ncbi.nlm.nih.gov/pubmed/31765407
http://dx.doi.org/10.1371/journal.pgen.1008427

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