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Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent

APO866 is a small molecule drug that specifically inhibits nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme involved in nicotinamide adenine dinucleotide (NAD) biosynthesis from the natural precursor nicotinamide. Although, the antitumor activity of APO866 on various types of cancer mode...

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Detalles Bibliográficos
Autores principales:	Cloux, Anne-Julie, Aubry, Dominique, Heulot, Mathieu, Widmann, Christian, ElMokh, Oussama, Piacente, Francesco, Cea, Michele, Nencioni, Alessio, Bellotti, Axel, Bouzourène, Karima, Pellegrin, Maxime, Mazzolai, Lucia, Duchosal, Michel A., Nahimana, Aimable
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877101/ https://www.ncbi.nlm.nih.gov/pubmed/31803365 http://dx.doi.org/10.18632/oncotarget.27336

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