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Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade

INTRODUCTION: Cytokine-based products are gaining importance for cancer immunotherapy. L19-TNF is a clinical-stage antibody-cytokine fusion protein that selectively accumulates to tumors and displays potent anticancer activity in preclinical models. Here, we describe an innovative approach to transi...

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Detalles Bibliográficos
Autores principales:	Dakhel, Sheila, Ongaro, Tiziano, Gouyou, Baptiste, Matasci, Mattia, Villa, Alessandra, Neri, Dario, Cazzamalli, Samuele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877107/ https://www.ncbi.nlm.nih.gov/pubmed/31803362 http://dx.doi.org/10.18632/oncotarget.27320

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