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Low Frequency Forced Oscillation Lung Function Test Can Distinguish Dynamic Tissue Non-linearity in COPD Patients
This paper introduces the use of low frequencies forced oscillation technique (FOT) in the presence of breathing signal. The hypothesis tested is to evaluate the sensitivity of FOT to various degrees of obstruction in COPD patients. The measurements were performed in the frequency range 0–2 Hz. The...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877497/ https://www.ncbi.nlm.nih.gov/pubmed/31803060 http://dx.doi.org/10.3389/fphys.2019.01390 |
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author | Ghita, Maria Copot, Dana Ghita, Mihaela Derom, Eric Ionescu, Clara |
author_facet | Ghita, Maria Copot, Dana Ghita, Mihaela Derom, Eric Ionescu, Clara |
author_sort | Ghita, Maria |
collection | PubMed |
description | This paper introduces the use of low frequencies forced oscillation technique (FOT) in the presence of breathing signal. The hypothesis tested is to evaluate the sensitivity of FOT to various degrees of obstruction in COPD patients. The measurements were performed in the frequency range 0–2 Hz. The use of FOT to evaluate respiratory impedance has been broadly recognized and its complementary use next to standardized method as spirometry and body plethysmography has been well-documented. Typical use of FOT uses frequencies between 4–32 Hz and above. However, interesting information at frequencies below 4 Hz is related to viscoelastic properties of parenchyma. Structural changes in COPD affect viscoelastic properties and we propose to investigate the use of FOT at low frequencies with a fourth generation fan-based FOT device. The generator non-linearity introduced by the device is separated from the linear approximation of the impedance before evaluating the results on patients. Three groups of COPD obstruction, GOLD II, III, and IV are evaluated. We found significant differences in mechanical parameters (tissue damping, tissue elasticity, hysteresivity) and increased degrees of non-linear dynamic contributions in the impedance data with increasing degree of obstruction (p < 0.01). The results obtained suggest that the non-linear index correlates better with degrees of heterogeneity linked to COPD GOLD stages, than the currently used hysteresivity index. The protocol and method may prove useful to improve current diagnosis percentages for various COPD phenotypes. |
format | Online Article Text |
id | pubmed-6877497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68774972019-12-04 Low Frequency Forced Oscillation Lung Function Test Can Distinguish Dynamic Tissue Non-linearity in COPD Patients Ghita, Maria Copot, Dana Ghita, Mihaela Derom, Eric Ionescu, Clara Front Physiol Physiology This paper introduces the use of low frequencies forced oscillation technique (FOT) in the presence of breathing signal. The hypothesis tested is to evaluate the sensitivity of FOT to various degrees of obstruction in COPD patients. The measurements were performed in the frequency range 0–2 Hz. The use of FOT to evaluate respiratory impedance has been broadly recognized and its complementary use next to standardized method as spirometry and body plethysmography has been well-documented. Typical use of FOT uses frequencies between 4–32 Hz and above. However, interesting information at frequencies below 4 Hz is related to viscoelastic properties of parenchyma. Structural changes in COPD affect viscoelastic properties and we propose to investigate the use of FOT at low frequencies with a fourth generation fan-based FOT device. The generator non-linearity introduced by the device is separated from the linear approximation of the impedance before evaluating the results on patients. Three groups of COPD obstruction, GOLD II, III, and IV are evaluated. We found significant differences in mechanical parameters (tissue damping, tissue elasticity, hysteresivity) and increased degrees of non-linear dynamic contributions in the impedance data with increasing degree of obstruction (p < 0.01). The results obtained suggest that the non-linear index correlates better with degrees of heterogeneity linked to COPD GOLD stages, than the currently used hysteresivity index. The protocol and method may prove useful to improve current diagnosis percentages for various COPD phenotypes. Frontiers Media S.A. 2019-11-19 /pmc/articles/PMC6877497/ /pubmed/31803060 http://dx.doi.org/10.3389/fphys.2019.01390 Text en Copyright © 2019 Ghita, Copot, Ghita, Derom and Ionescu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Ghita, Maria Copot, Dana Ghita, Mihaela Derom, Eric Ionescu, Clara Low Frequency Forced Oscillation Lung Function Test Can Distinguish Dynamic Tissue Non-linearity in COPD Patients |
title | Low Frequency Forced Oscillation Lung Function Test Can Distinguish Dynamic Tissue Non-linearity in COPD Patients |
title_full | Low Frequency Forced Oscillation Lung Function Test Can Distinguish Dynamic Tissue Non-linearity in COPD Patients |
title_fullStr | Low Frequency Forced Oscillation Lung Function Test Can Distinguish Dynamic Tissue Non-linearity in COPD Patients |
title_full_unstemmed | Low Frequency Forced Oscillation Lung Function Test Can Distinguish Dynamic Tissue Non-linearity in COPD Patients |
title_short | Low Frequency Forced Oscillation Lung Function Test Can Distinguish Dynamic Tissue Non-linearity in COPD Patients |
title_sort | low frequency forced oscillation lung function test can distinguish dynamic tissue non-linearity in copd patients |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877497/ https://www.ncbi.nlm.nih.gov/pubmed/31803060 http://dx.doi.org/10.3389/fphys.2019.01390 |
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