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Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease
We previously demonstrated that a common dietary protein component, wheat amylase trypsin inhibitors (ATI), stimulate intestinal macrophages and dendritic cells via toll like receptor 4. Activation of these intestinal myeloid cells elicits an inflammatory signal that is propagated to mesenteric lymp...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877510/ https://www.ncbi.nlm.nih.gov/pubmed/31767938 http://dx.doi.org/10.1038/s41598-019-53323-x |
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author | Ashfaq-Khan, Muhammad Aslam, Misbah Qureshi, Muhammad Asif Senkowski, Marcel Sascha Yen-Weng, Shih Strand, Susanne Kim, Yong Ook Pickert, Geethanjali Schattenberg, Jörn M. Schuppan, Detlef |
author_facet | Ashfaq-Khan, Muhammad Aslam, Misbah Qureshi, Muhammad Asif Senkowski, Marcel Sascha Yen-Weng, Shih Strand, Susanne Kim, Yong Ook Pickert, Geethanjali Schattenberg, Jörn M. Schuppan, Detlef |
author_sort | Ashfaq-Khan, Muhammad |
collection | PubMed |
description | We previously demonstrated that a common dietary protein component, wheat amylase trypsin inhibitors (ATI), stimulate intestinal macrophages and dendritic cells via toll like receptor 4. Activation of these intestinal myeloid cells elicits an inflammatory signal that is propagated to mesenteric lymph nodes, and that can facilitate extraintestinal inflammation. Mice were fed a well-defined high fat diet, with (HFD/ATI) or without (HFD) nutritionally irrelevant amounts of ATI. Mice on HFD/ATI developed only mild signs of intestinal inflammation and myeloid cell activation but displayed significantly higher serum triglycerides and transaminases compared to mice on HFD alone. Moreover, they showed increased visceral and liver fat, and a higher insulin resistance. ATI feeding promoted liver and adipose tissue inflammation, with M1-type macrophage polarization and infiltration, and enhanced liver fibrogenesis. Gluten, the major protein component of wheat, did not induce these pathologies. Therefore, wheat ATI ingestion in minute quantities comparable to human daily wheat consumption exacerbated features of the metabolic syndrome and non-alcoholic steatohepatitis, despite its irrelevant caloric value. |
format | Online Article Text |
id | pubmed-6877510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68775102019-12-05 Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease Ashfaq-Khan, Muhammad Aslam, Misbah Qureshi, Muhammad Asif Senkowski, Marcel Sascha Yen-Weng, Shih Strand, Susanne Kim, Yong Ook Pickert, Geethanjali Schattenberg, Jörn M. Schuppan, Detlef Sci Rep Article We previously demonstrated that a common dietary protein component, wheat amylase trypsin inhibitors (ATI), stimulate intestinal macrophages and dendritic cells via toll like receptor 4. Activation of these intestinal myeloid cells elicits an inflammatory signal that is propagated to mesenteric lymph nodes, and that can facilitate extraintestinal inflammation. Mice were fed a well-defined high fat diet, with (HFD/ATI) or without (HFD) nutritionally irrelevant amounts of ATI. Mice on HFD/ATI developed only mild signs of intestinal inflammation and myeloid cell activation but displayed significantly higher serum triglycerides and transaminases compared to mice on HFD alone. Moreover, they showed increased visceral and liver fat, and a higher insulin resistance. ATI feeding promoted liver and adipose tissue inflammation, with M1-type macrophage polarization and infiltration, and enhanced liver fibrogenesis. Gluten, the major protein component of wheat, did not induce these pathologies. Therefore, wheat ATI ingestion in minute quantities comparable to human daily wheat consumption exacerbated features of the metabolic syndrome and non-alcoholic steatohepatitis, despite its irrelevant caloric value. Nature Publishing Group UK 2019-11-25 /pmc/articles/PMC6877510/ /pubmed/31767938 http://dx.doi.org/10.1038/s41598-019-53323-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ashfaq-Khan, Muhammad Aslam, Misbah Qureshi, Muhammad Asif Senkowski, Marcel Sascha Yen-Weng, Shih Strand, Susanne Kim, Yong Ook Pickert, Geethanjali Schattenberg, Jörn M. Schuppan, Detlef Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease |
title | Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease |
title_full | Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease |
title_fullStr | Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease |
title_full_unstemmed | Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease |
title_short | Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease |
title_sort | dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877510/ https://www.ncbi.nlm.nih.gov/pubmed/31767938 http://dx.doi.org/10.1038/s41598-019-53323-x |
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