Global alteration of T-lymphocyte metabolism by PD-L1 checkpoint involves a block of de novo nucleoside phosphate synthesis

Metabolic obstacles of the tumor microenvironment remain a challenge to T-cell-mediated cancer immunotherapies. To better understand the interplay of immune checkpoint signaling and immune metabolism, this study developed and used an optimized metabolite extraction protocol for non-adherent primary...

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Detalles Bibliográficos
Autores principales: Palaskas, Nicolaos Jay, Garcia, Jacob David, Shirazi, Roksana, Shin, Daniel Sanghoon, Puig-Saus, Cristina, Braas, Daniel, Ribas, Antoni, Graeber, Thomas Glen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877514/
https://www.ncbi.nlm.nih.gov/pubmed/31798961
http://dx.doi.org/10.1038/s41421-019-0130-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877514/
https://www.ncbi.nlm.nih.gov/pubmed/31798961
http://dx.doi.org/10.1038/s41421-019-0130-x

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