Oxidation of difluorocarbene and subsequent trifluoromethoxylation

As a versatile intermediate, difluorocarbene is an electron-deficient transient species, meaning that its oxidation would be challenging. Herein we show that the oxidation of difluorocarbene could occur smoothly to generate carbonyl fluoride. The oxidation process is confirmed by successful trifluor...

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Detalles Bibliográficos
Autores principales: Yu, Jiao, Lin, Jin-Hong, Yu, Donghai, Du, Ruobing, Xiao, Ji-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877537/
https://www.ncbi.nlm.nih.gov/pubmed/31767850
http://dx.doi.org/10.1038/s41467-019-13359-z
Descripción
Sumario:As a versatile intermediate, difluorocarbene is an electron-deficient transient species, meaning that its oxidation would be challenging. Herein we show that the oxidation of difluorocarbene could occur smoothly to generate carbonyl fluoride. The oxidation process is confirmed by successful trifluoromethoxylation, (18)O-trifluoromethoxylation, the observation of AgOCF(3) species, and DFT calculations.

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